Journal Article

DZNE-2020-07883

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png RIM-BP2 primes synaptic vesicles via recruitment of Munc13-1 at hippocampal mossy fiber synapses.

Brockmann, M. M. ; Maglione, M. ; Willmes, C. G. ; Stumpf, A. ; Bouazza, B. A. ; Velasquez, L. M. ; Grauel, M. K. ; Beed, P. ; Lehmann, M. ; Gimber, N. ; Schmoranzer, J. ; Sigrist, S. J.DZNE* ; Rosenmund, C. ; Schmitz, D. (Last author)DZNE*

2019
eLife Sciences Publications Cambridge

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Please use a persistent id in citations: doi:10.7554/eLife.43243

Abstract: All synapses require fusion-competent vesicles and coordinated Ca2+-secretion coupling for neurotransmission, yet functional and anatomical properties are diverse across different synapse types. We show that the presynaptic protein RIM-BP2 has diversified functions in neurotransmitter release at different central murine synapses and thus contributes to synaptic diversity. At hippocampal pyramidal CA3-CA1 synapses, RIM-BP2 loss has a mild effect on neurotransmitter release, by only regulating Ca2+-secretion coupling. However, at hippocampal mossy fiber synapses, RIM-BP2 has a substantial impact on neurotransmitter release by promoting vesicle docking/priming and vesicular release probability via stabilization of Munc13-1 at the active zone. We suggest that differences in the active zone organization may dictate the role a protein plays in synaptic transmission and that differences in active zone architecture is a major determinant factor in the functional diversity of synapses.

Keyword(s): Intracellular Signaling Peptides and Proteins: metabolism (MeSH) ; Animals (MeSH) ; Mice (MeSH) ; Mossy Fibers, Hippocampal: metabolism (MeSH) ; Nerve Tissue Proteins: metabolism (MeSH) ; Neurons: metabolism (MeSH) ; Neurotransmitter Agents: metabolism (MeSH) ; Synaptic Vesicles: metabolism (MeSH) ; Nerve Tissue Proteins ; Neurotransmitter Agents ; Unc13a protein, mouse

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Contributing Institute(s):

1. Aging of Synapse Structure and Function (AG Sigrist)
2. Network Dysfunction (AG Schmitz)

Research Program(s):

1. 341 - Molecular Signaling (POF3-341) (POF3-341)

Appears in the scientific report 2019

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Database coverage:
; ; ; ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Ebsco Academic Search ; IF >= 5 ; JCR ; SCOPUS ; Web of Science Core Collection ; Zoological Record

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