Journal Article

DZNE-2020-00004

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Genetic variation at the synaptic vesicle gene SV2A is associated with schizophrenia.

Mattheisen, M. ; Mühleisen, T. W. ; Strohmaier, J. ; Treutlein, J. ; Nenadic, I. ; Alblas, M. ; Meier, S. ; Degenhardt, F. ; Herms, S. ; Hoffmann, P. ; Witt, S. H. ; Giegling, I. ; Sauer, H. ; Schulze, T. G. ; Rujescu, D. ; Nöthen, M. M.DZNE* ; Rietschel, M. ; Cichon, S. (Corresponding author)

2012
Elsevier Science Amsterdam [u.a.]

This record in other databases:    

Please use a persistent id in citations: doi:10.1016/j.schres.2012.08.027

Abstract: Convergent evidence from pharmacological and animal studies suggests a possible role for the synaptic vesicle glycoprotein 2A gene (SV2A) in schizophrenia susceptibility. To test systematically all common variants in the SV2A gene region for an association with schizophrenia, we used a HapMap-based haplotype tagging approach and tested five SNPs in 794 patients and 843 controls. The SNP rs15931 showed evidence for an association with schizophrenia and was followed-up in an independent sample of 2581 individuals (overall p-value=0.0042, OR=0.779). Our study in the German population provides evidence, at a genetic level, for the involvement of the SV2A gene region in schizophrenia.

Keyword(s): Membrane Glycoproteins ; Nerve Tissue Proteins ; SV2A protein, human

---

Contributing Institute(s):

1. Bonn common (Bonn common)

Research Program(s):

1. 345 - Population Studies and Genetics (POF3-345) (POF3-345)

Appears in the scientific report 2012

---

Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Current Contents - Social and Behavioral Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Social Sciences Citation Index ; Web of Science Core Collection

---