Journal Article

DZNE-2020-00328

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Gait analysis with wearables predicts conversion to parkinson disease.

Del Din, S. ; Elshehabi, M.DZNE* ; Galna, B. ; Hobert, M. A.DZNE* ; Warmerdam, E. ; Sünkel, U.DZNE* ; Brockmann, K.DZNE* ; Metzger, F.DZNE* ; Hansen, C. ; Berg, D.DZNE* ; Rochester, L. ; Maetzler, W. (Last author)DZNE*

2019
Wiley-Blackwell Hoboken, NJ

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Please use a persistent id in citations: doi:10.1002/ana.25548

Abstract: Quantification of gait with wearable technology is promising; recent cross-sectional studies showed that gait characteristics are potential prodromal markers for Parkinson disease (PD). The aim of this longitudinal prospective observational study was to establish gait impairments and trajectories in the prodromal phase of PD, identifying which gait characteristics are potentially early diagnostic markers of PD.The 696 healthy controls (mean age = 63 ± 7 years) recruited in the Tubingen Evaluation of Risk Factors for Early Detection of Neurodegeneration study were included. Assessments were performed longitudinally 4 times at 2-year intervals, and people who converted to PD were identified. Participants were asked to walk at different speeds under single and dual tasking, with a wearable device placed on the lower back; 14 validated clinically relevant gait characteristics were quantified. Cox regression was used to examine whether gait at first visit could predict time to PD conversion after controlling for age and sex. Random effects linear mixed models (RELMs) were used to establish longitudinal trajectories of gait and model the latency between impaired gait and PD diagnosis.Sixteen participants were diagnosed with PD on average 4.5 years after first visit (converters; PDC). Higher step time variability and asymmetry of all gait characteristics were associated with a shorter time to PD diagnosis. RELMs indicated that gait (lower pace) deviates from that of non-PDC approximately 4 years prior to diagnosis.Together with other prodromal markers, quantitative gait characteristics can play an important role in identifying prodromal PD and progression within this phase. ANN NEUROL 2019;86:357-367.

Keyword(s): Disease Progression (MeSH) ; Early Diagnosis (MeSH) ; Female (MeSH) ; Gait Analysis (MeSH) ; Humans (MeSH) ; Linear Models (MeSH) ; Longitudinal Studies (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Parkinson Disease: diagnosis (MeSH) ; Parkinson Disease: physiopathology (MeSH) ; Prodromal Symptoms (MeSH) ; Prospective Studies (MeSH) ; Time Factors (MeSH) ; Walking (MeSH) ; Wearable Electronic Devices (MeSH)

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Contributing Institute(s):

1. Functional Neurogeriatrics (AG Maetzler)
2. Ext Universitätsklinikum Tübingen (Ext UKT)
3. Core ICRU (ICRU)
4. Parkinson Genetics (AG Gasser)
5. Parkinson's Disease Genetics (AG Berg)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)
2. 345 - Population Studies and Genetics (POF3-345) (POF3-345)

Appears in the scientific report 2019

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 10 ; JCR ; Nationallizenz ; SCOPUS ; Web of Science Core Collection

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