Abstract/Journal Article

DZNE-2020-00682

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png E-PW081: In vivo Imaging of Microglial Activation in Patients with Clinical Suspected Progressive Supranuclear Palsy: A 18F-GE180 PET study

Zwingmann, I.DZNE* ; Dietzel, K.DZNE* ; Wernecke, K.DZNE* ; Eßer, A.DZNE* ; Monsees, J.DZNE* ; Hoffmann, W.DZNE*

2018

Abstract: Progressive supranuclear palsy (PSP) is a4R-tauopathy with a severe clinical course. The pathophysiological processes are not sufficiently understood and a causaltherapy for this life limiting disease is still missing. The neuropathological hallmark of PSP are accumulated tau protein fibrilsthat were claimed to be responsible for following neurodegeneration. Microglial activation has been shown to occur in PSP asanother hallmark of the disease. Therefore, we aimed to establish in vivo imaging of microglial activity by 18kDa translocatorprotein (TSPO) PET.

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Contributing Institute(s):

1. Translational Health Care Research (AG Hoffmann)
2. Interventional Health Care Research (IHCR) (AG Thyrian)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2018

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 10 ; JCR ; SCOPUS ; Web of Science Core Collection

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