Abstract/Journal Article

DZNE-2020-00744

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Parkinson's Disease Risk Is Associated with Variants in Genes That Bind Bacterial Cell-Wall Peptidoglycan (P05.051)

Goldman, S. ; Jewell, S.DZNE* ; Meng, C. ; Ross, W. ; Chade, A. ; Kasten, M. ; Bhudhikanok, G. ; Comyns, K. ; Korell, M. ; Langston, J. ; Tanner, C.

2013

Abstract: AbstractOBJECTIVE: To investigate the possible association of Parkinson's disease (PD) risk with variants in genes involved in the binding of bacterial cell-wall peptidoglycan.BACKGROUND: Peptidoglycan is a structural component of the bacterial cell wall, which binds recognition proteins encoded by PGLYRP genes. Peptidoglycan-recognition-proteins play a role in maintenance of healthy gut microbial flora and immune system activation. Lipopolysaccharide (LPS) from the cell membrane of gram negative bacteria has been shown to induce a parkinsonian syndrome in animal models, but peptidoglycan has not been well-studied.

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Contributing Institute(s):

1. Scientific Strategy Unit (Scientific Strategy Unit)

Research Program(s):

1. 345 - Population Studies and Genetics (POF3-345) (POF3-345)

Appears in the scientific report 2013

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Database coverage:
; Allianz-Lizenz ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Essential Science Indicators ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; PubMed Central ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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