Abstract/Journal Article

DZNE-2020-01021

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Understanding the role of ADAM15 in osteoarthritis

Yang, C. Y. ; Chanalaris, A. ; Scilabra, S.DZNE* ; Lichtenthaler, S.DZNE* ; Nagase, L. ; Troeberg, H.

2017

Abstract: Introduction A disintegrin and metalloproteinase 15(ADAM15) is a member of the ADAM family of metallo-proteinases, which are functionally important enzymesinvolved in a wide variety of biological functions. A previ-ous study on Adam15-null mice demonstrated that malemice lacking ADAM15 developed accelerated age-relatedosteoarthritis (OA), suggesting that ADAM15 has chon-droprotective effects in OA. Despite its potentially impor-tant biological role, little is known about how ADAM15 isregulated in cartilage.

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Contributing Institute(s):

1. Neuroproteomics (AG Lichtenthaler)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2017

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Web of Science Core Collection

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