Journal Article

DZNE-2020-01096

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Intraindividual Neurofilament Dynamics in Serum Mark the Conversion to Sporadic Parkinson's Disease

Wilke, C. (First author)DZNE* ; Santos, M. C. T. ; Schulte, C.DZNE* ; Deuschle, C.DZNE* ; Scheller, D. ; Verbelen, M. ; Brockmann, K.DZNE* ; von Thaler, A.-K.DZNE* ; Sünkel, U.DZNE* ; Roeben, B.DZNE* ; Bujac, S. ; Metzger, F. G. ; Maetzler, W. ; Costa, A. N. ; Synofzik, M.DZNE* ; Berg, D.

2020
Wiley New York, NY

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Please use a persistent id in citations: doi:10.1002/mds.28026

Abstract: Background and ObjectivesWith disease‐modifying treatment strategies on the horizon, stratification of individual patients at the earliest stages of Parkinson's disease (PD) is key—ideally already at clinical disease onset. Blood levels of neurofilament light chain (NfL) provide an easily accessible fluid biomarker that might allow capturing the conversion from prodromal to manifest PD.MethodsWe assessed longitudinal serum NfL levels in subjects converting from prodromal to manifest sporadic PD (converters), at‐risk subjects, and matched controls (72 participants with ≈4 visits), using single‐molecule array (Simoa) technique.ResultsWhile NfL levels were not increased at the prodromal stage, subjects converting to the manifest motor stage showed a significant intraindividual acceleration of the age‐dependent increase of NfL levels.ConclusionsThe temporal dynamics of intraindividual NfL blood levels might mark the conversion to clinically manifest PD, providing a potential stratification biomarker for individual disease onset in the advent of precision medicine for PD. © 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

Keyword(s): Biomarkers (MeSH) ; Humans (MeSH) ; Intermediate Filaments (MeSH) ; Neurofilament Proteins (MeSH) ; Parkinson Disease (MeSH) ; Prodromal Symptoms (MeSH)

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Contributing Institute(s):

1. Core ICRU (Core ICRU)
2. Parkinson's Disease Genetics (AG Berg ; AG Berg)
3. Parkinson Genetics (AG Gasser 1)

Research Program(s):

1. 345 - Population Studies and Genetics (POF3-345) (POF3-345)

Appears in the scientific report 2020

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Web of Science Core Collection

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