Journal Article (Letter)

DZNE-2020-01374

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Insulin Sensitivity in De Novo Parkinson's Disease: A Hyperinsulinemic-Euglycemic Clamp Study.

Aziz, A. (First author)DZNE* ; Roos, R. A. C. ; Pijl, H.

2020
Wiley New York, NY

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Please use a persistent id in citations: doi:10.1002/mds.28181

Abstract: A recent clinical trial found that exenatide, an antidiabeticdrug, could slow down the rate of decline in motor perfor-mance in patients with Parkinson’s disease (PD).1A higherprevalence of diabetes mellitus (DM) has been reported in PDpatients,2whereas an increased incidence of PD was found inpatients with DM.3–5Although these ndings suggest thatperipheral insulin resistance might be involved in PDpathogenesis,6systemic substrate metabolism and its respon-siveness to insulin stimulation have not been rigorouslyassessed before in de novo, medication-free PD patients. There-fore, using the hyperinsulinemic-euglycemic clamp technique,the most accurate and precise method available for quantifyinginsulin sensitivity, we aimed to assess whether insulin resistanceis an inherent feature of PD.

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Contributing Institute(s):

1. Population Health Sciences (AG Breteler 1)
2. Population & Clinical Neuroepidemiology (AG Aziz)

Research Program(s):

1. 345 - Population Studies and Genetics (POF3-345) (POF3-345)

Appears in the scientific report 2020

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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