Journal Article

DZNE-2021-00036

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Greater male than female variability in regional brain structure across the lifespan

Wierenga, L. M. ; Netherlands}, C. L. T. ; Doucet, G. E. ; Dima, D. ; UK}, N. K. C. L. L. ; Agartz, I. ; Aghajani, M. ; Family, C. S. F. ; Akudjedu, T. N. ; Albajes-Eizagirre, A. ; Alnæs, D. ; Alpert, K. I. ; Andreassen, O. A. ; Anticevic, A. ; Asherson, P. ; Banaschewski, T. ; Psychiatry, A. ; Bargallo, N. ; Baumeister, S. ; Psychiatry, A. ; Baur-Streubel, R. ; Bertolino, A. ; Bonvino, A. ; Boomsma, D. I. ; Borgwardt, S. ; Bourque, J. ; Braber, A. ; Brandeis, D. ; Breier, A. ; Brodaty, H. ; Brouwer, R. M. ; Buitelaar, J. K. ; Busatto, G. F. ; Calhoun, V. D. ; Canales-Rodríguez, E. J. ; Cannon, D. M. ; Caseras, X. ; Castellanos, F. X. ; Chaim-Avancini, T. M. ; Ching, C. R. ; Neuroimaging, M. S. ; Clark, V. P. ; Conrod, P. J. ; Conzelmann, A. ; Crivello, F. ; Davey, C. G. ; Dickie, E. W. ; Ehrlich, S. ; Ent, D. ; Fisher, S. E. ; Fouche, J.-P. ; Franke, B. ; Fuentes-Claramonte, P. ; Geus, E. J. ; Di Giorgio, A. ; Glahn, D. C. ; Gotlib, I. H. ; Grabe, H. J.DZNE* ; Gruber, O. ; Gruner, P. ; Gur, R. E. ; Gur, R. C. ; Gurholt, T. P. ; Haan, L. ; Haatveit, B. ; Harrison, B. J. ; Hartman, C. A. ; Hatton, S. N. ; Heslenfeld, D. J. ; Heuvel, O. A. ; Hickie, I. B. ; Hoekstra, P. J. ; Hohmann, S. ; Holmes, A. J. ; Hoogman, M. ; Hosten, N. ; Howells, F. M. ; Hulshoff Pol, H. E. ; Huyser, C. ; Jahanshad, N. ; James, A. C. ; Jiang, J. ; Jönsson, E. G. ; Joska, J. A. ; Kalnin, A. J. ; Klein, M. ; Koenders, L. ; Kolskår, K. K. ; Krämer, B. ; Kuntsi, J. ; Lagopoulos, J. ; Lazaro, L. ; Lebedeva, I. S. ; Lee, P. H. ; Lochner, C. ; Machielsen, M. W. ; Maingault, S. ; Martin, N. G. ; Martínez-Zalacaín, I. ; Mataix-Cols, D. ; Mazoyer, B. ; McDonald, B. C. ; McDonald, C. ; McIntosh, A. M. ; McMahon, K. L. ; McPhilemy, G. ; Meer, D. ; Menchón, J. M. ; Naaijen, J. ; Nyberg, L. ; Oosterlaan, J. ; Paloyelis, Y. ; Pauli, P. ; Pergola, G. ; Pomarol-Clotet, E. ; Portella, M. J. ; Radua, J. ; Reif, A. ; Richard, G. ; Roffman, J. L. ; Rosa, P. G. ; Sacchet, M. D. ; Sachdev, P. S. ; Salvador, R. ; Sarró, S. ; Satterthwaite, T. D. ; Saykin, A. J. ; Serpa, M. H. ; Sim, K. ; Simmons, A. ; Smoller, J. W. ; Sommer, I. E. ; Soriano-Mas, C. ; Stein, D. J. ; Strike, L. T. ; Szeszko, P. R. ; Temmingh, H. S. ; Thomopoulos, S. I. ; Tomyshev, A. S. ; Trollor, J. N. ; Uhlmann, A. ; Psychiatry, A. ; Veer, I. M. ; Veltman, D. J. ; Voineskos, A. ; Völzke, H. ; Walter, H. ; Wang, L. ; Wang, Y. ; Weber, B. ; Wen, W. ; West, J. D. ; Westlye, L. T. ; Whalley, H. C. ; Williams, S. C. ; Wittfeld, K.DZNE* ; Wolf, D. H. ; Wright, M. J. ; Yoncheva, Y. N. ; Zanetti, M. V. ; Ziegler, G. C. ; Zubicaray, G. I. ; Thompson, P. M. ; Crone, E. A. ; Frangou, S. ; Tamnes, C. K.

2022
Wiley-Liss New York, NY

This record in other databases:    

Please use a persistent id in citations: doi:10.1002/hbm.25204

Abstract: For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta‐Analysis) Consortium presents the largest‐ever mega‐analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1‐90 years old (47% females). We observed significant patterns of greater male than female between‐subject variance for all subcortical volumetric measures, all cortical surface area measures, and 60% of cortical thickness measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene‐environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex‐specific vulnerability to disorders.

Keyword(s): Biological Variation, Population: physiology (MeSH) ; Brain: anatomy & histology (MeSH) ; Brain: diagnostic imaging (MeSH) ; Brain Cortical Thickness (MeSH) ; Cerebral Cortex: anatomy & histology (MeSH) ; Cerebral Cortex: diagnostic imaging (MeSH) ; Female (MeSH) ; Human Development: physiology (MeSH) ; Humans (MeSH) ; Magnetic Resonance Imaging (MeSH) ; Male (MeSH) ; Neuroimaging (MeSH) ; Sex Characteristics (MeSH)

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Contributing Institute(s):

1. Clinical Research (Munich) (Clinical Research (Munich))
2. Biomarkers of Dementia in the General Population (AG Grabe)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)
2. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2020

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Database coverage:
; ; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; DOAJ Seal ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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