Journal Article

DZNE-2021-00081

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The temporal association between incident late-life depression and incident dementia.

Heser, K. (First author)DZNE* ; Fink, A.DZNE* ; Reinke, C. ; Wagner, M.DZNE* ; Doblhammer-Reiter, G. (Last author)DZNE*

2020
Blackwell71350 Oxford

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Please use a persistent id in citations: doi:10.1111/acps.13220

Abstract: There is an established association between depression and subsequent dementia. The present study examined temporal associations between incident late-life depression and subsequent dementia, also considering age and sex.We used longitudinal health claims data from the largest German health insurance provider ('Allgemeine Ortskrankenkasse') considering up to 9 follow-up years in piecewise exponential models. ICD-10 codes were used to define incident depression and dementia in individuals ≥65 years (n = 97 110).Incident depression was associated with a higher risk of subsequent dementia (incidence rate ratios (IRR) adjusted for age and sex: IRR = 1.58, 95% CI = 1.51-1.64). The strongest association was found for the shortest interval of 1 quarter (IRR = 2.04, 95% CI = 1.88-2.21), with significant associations up to an interval of roughly 3 years. The association was more pronounced and lasted for more quarters in the younger portion of this study group (ages from 65-74: IRR = 2.00, 95% CI = 1.83-2.18; 75-84: IRR = 1.64, 95% CI = 1.55-1.73; ≥85: IRR = 1.19, 95% CI = 1.08-1.31). It was stronger among men than women (men: IRR = 1.98, 95% CI = 1.84-2.14; women: IRR = 1.44, 95% CI = 1.37-1.51) with no sex-specific temporal association.This large claims data study confirmed that incident late-life depression is associated with a higher risk of dementia within the 3 years following diagnosis. Hence, incident late-life depression should prompt further cognitive examinations and referrals to specialists. This might apply especially to younger seniors and men.

Keyword(s): Dementia: epidemiology (MeSH) ; Depression: epidemiology (MeSH) ; Female (MeSH) ; Humans (MeSH) ; Incidence (MeSH) ; Male (MeSH) ; Risk Factors (MeSH) ; dementia ; depression ; epidemiology

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Contributing Institute(s):

1. Demographic Studies (AG Doblhammer-Reiter)
2. Neuropsychology (AG Wagner)

Research Program(s):

1. 341 - Molecular Signaling (POF3-341) (POF3-341)

Appears in the scientific report 2020

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Database coverage:
; ; ; Biological Abstracts ; Ebsco Academic Search ; Essential Science Indicators ; SCOPUS ; Science Citation Index Expanded

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