Journal Article

DZNE-2021-00164

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Denser brain capillary network with preserved pericytes in Alzheimer's disease.

Fernandez-Klett, F. ; Brandt, L. ; Fernández-Zapata, C. ; Abuelnor, B. ; Middeldorp, J. ; Sluijs, J. A. ; Curtis, M. ; Faull, R. ; Harris, L. W. ; Bahn, S. ; Hol, E. M. ; Priller, J. (Last author)DZNE*

2020
Wiley-Blackwell Oxford

This record in other databases:    

Please use a persistent id in citations: doi:10.1111/bpa.12897

Abstract: Pericytes are vascular mural cells that surround capillaries of the central nervous system (CNS). They are crucial for brain development and contribute to CNS homeostasis by regulating blood-brain barrier function and cerebral blood flow. It has been suggested that pericytes are lost in Alzheimer's disease (AD), implicating this cell type in disease pathology. Here, we have employed state-of-the-art stereological morphometry techniques as well as tissue clearing and two-photon imaging to assess the distribution of pericytes in two independent cohorts of AD (n = 16 and 13) and non-demented controls (n = 16 and 4). Stereological quantification revealed increased capillary density with a normal pericyte population in the frontal cortex of AD brains, a region with early amyloid β deposition. Two-photon analysis of cleared frontal cortex tissue confirmed the preservation of pericytes in AD cases. These results suggest that pericyte demise is not a general hallmark of AD pathology.

Keyword(s): Aged (MeSH) ; Aged, 80 and over (MeSH) ; Alzheimer Disease: metabolism (MeSH) ; Alzheimer Disease: pathology (MeSH) ; Amyloid beta-Peptides: metabolism (MeSH) ; Blood-Brain Barrier: metabolism (MeSH) ; Blood-Brain Barrier: pathology (MeSH) ; Capillaries: metabolism (MeSH) ; Capillaries: pathology (MeSH) ; Cerebrovascular Circulation: physiology (MeSH) ; Female (MeSH) ; Frontal Lobe: metabolism (MeSH) ; Frontal Lobe: pathology (MeSH) ; Humans (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Peptide Fragments: metabolism (MeSH) ; Pericytes: metabolism (MeSH) ; Pericytes: pathology (MeSH) ; Alzheimer's disease (AD) ; angiogenesis ; blood-brain barrier (BBB) ; capillaries ; clarity ; pericytes ; stereology ; two-photon microscopy

Note: ISSN 1750-3639 not unique: **3 hits**.

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Contributing Institute(s):

1. Translational Neuropsychiatry (AG Priller)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2020

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Database coverage:
; ; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; DOAJ Seal ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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