Journal Article

DZNE-2021-00186

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Levodopa-Induced Dyskinesia Are Mediated by Cortical Gamma Oscillations in Experimental Parkinsonism.

Güttler, C. ; Altschüler, J. ; Tanev, K. ; Böckmann, S. ; Haumesser, J. K. ; Nikulin, V. V. ; Kühn, A.DZNE* ; van Riesen, C. (Last author)DZNE*

2021
Wiley New York, NY

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Please use a persistent id in citations: doi:10.1002/mds.28403

Abstract: Levodopa is the most efficacious drug in the symptomatic therapy of motor symptoms in Parkinson's disease (PD); however, long-term treatment is often complicated by troublesome levodopa-induced dyskinesia (LID). Recent evidence suggests that LID might be related to increased cortical gamma oscillations.The objective of this study was to test the hypothesis that cortical high-gamma network activity relates to LID in the 6-hydroxydopamine model and to identify new biomarkers for adaptive deep brain stimulation (DBS) therapy in PD.We recorded and analyzed primary motor cortex (M1) electrocorticogram data and motor behavior in freely moving 6-OHDA lesioned rats before and during a daily treatment with levodopa for 3 weeks. The results were correlated with the abnormal involuntary movement score (AIMS) and used for generalized linear modeling (GLM).Levodopa reverted motor impairment, suppressed beta activity, and, with repeated administration, led to a progressive enhancement of LID. Concurrently, we observed a highly significant stepwise amplitude increase in finely tuned gamma (FTG) activity and gamma centroid frequency. Whereas AIMS and FTG reached their maximum after the 4th injection and remained on a stable plateau thereafter, the centroid frequency of the FTG power continued to increase thereafter. Among the analyzed gamma activity parameters, the fraction of longest gamma bursts showed the strongest correlation with AIMS. Using a GLM, it was possible to accurately predict AIMS from cortical recordings.FTG activity is tightly linked to LID and should be studied as a biomarker for adaptive DBS. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyword(s): Animals (MeSH) ; Antiparkinson Agents: adverse effects (MeSH) ; Disease Models, Animal (MeSH) ; Dyskinesia, Drug-Induced: etiology (MeSH) ; Levodopa: adverse effects (MeSH) ; Oxidopamine: toxicity (MeSH) ; Parkinson Disease (MeSH) ; Parkinsonian Disorders: chemically induced (MeSH) ; Parkinsonian Disorders: drug therapy (MeSH) ; Rats (MeSH) ; 6-OHDA ; dyskinesia ; gamma oscillations

Note: ISSN 1531-8257 not unique: **3 hits**.

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Contributing Institute(s):

1. Epigenetics and Systems Medicine in Neurodegenerative Diseases (AG Fischer)
2. Interdisciplinary Dementia Research (AG Endres)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)
2. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2021

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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Linked articles:

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Journal Article (Editorial) Güttler, C. ; Nikulin, V. V. ; van Riesen, C. (Last author)DZNE*
Reply to: 'Levodopa-Induced Dyskinesia Is Mediated by Cortical Gamma Oscillations in Experimental Parkinsonism'.
Movement disorders 36(4), 1045 - 1047 (2021) [10.1002/mds.28576]2021 BibTeX | EndNote: XML, Text | RIS

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