Journal Article

DZNE-2021-00189

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png TDP-43 as structure-based biomarker in amyotrophic lateral sclerosis.

Beyer, L. ; Günther, R.DZNE* ; Koch, J. C. ; Klebe, S. ; Hagenacker, T. ; Lingor, P. ; Biesalski, A.-S. ; Hermann, A.DZNE* ; Nabers, A. ; Gold, R. ; Tönges, L. ; Gerwert, K.

2021
Wiley Chichester [u.a.]

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Please use a persistent id in citations: doi:10.1002/acn3.51256

Abstract: Pathologic alterations of Transactivation response DNA-binding protein 43 kilo Dalton (TDP-43) are a major hallmark of amyotrophic lateral sclerosis (ALS). In this pilot study, we analyzed the secondary structure distribution of TDP-43 in cerebrospinal fluid of ALS patients (n = 36) compared to Parkinson´s disease patients (PD; n = 30) and further controls (Ctrl; n = 24) using the immuno-infrared sensor technology. ALS patients could be discriminated from PD and Ctrl with a sensitivity/specificity of 89 %/77 % and 89 %/83 %, respectively. Our findings demonstrate that TDP-43 misfolding measured by the immuno-infrared sensor technology has the potential to serve as a biomarker candidate for ALS.

Keyword(s): Aged (MeSH) ; Amyotrophic Lateral Sclerosis: cerebrospinal fluid (MeSH) ; Amyotrophic Lateral Sclerosis: diagnosis (MeSH) ; Biomarkers: cerebrospinal fluid (MeSH) ; DNA-Binding Proteins: cerebrospinal fluid (MeSH) ; DNA-Binding Proteins: chemistry (MeSH) ; Female (MeSH) ; Humans (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Pilot Projects (MeSH) ; Protein Structure, Secondary (MeSH) ; Sensitivity and Specificity (MeSH) ; Spectrophotometry, Infrared: methods (MeSH)

Note: ISSN 2328-9503 not unique: **3 hits**.

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Contributing Institute(s):

1. Translational Neurodegeneration (AG Hermann)
2. Translational Studies and Biomarker (AG Zerr)
3. Clinical Dementia Research (Rostock /Greifswald) (AG Teipel)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2021

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Database coverage:
; ; ; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Ebsco Academic Search ; Essential Science Indicators ; Fees ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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