Journal Article (Review Article)

DZNE-2022-00251

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Current challenges in reliably targeting the noradrenergic locus coeruleus using transcutaneous auricular vagus nerve stimulation (taVNS).

Ludwig, M. ; Wienke, C.Extern* ; Betts, M. J.DZNE* ; Zähle, T.Extern* ; Hämmerer, D.Extern*

2021
Elsevier Science Amsterdam [u.a.]

This record in other databases:    

Please use a persistent id in citations: doi:10.1016/j.autneu.2021.102900

Abstract: Transcutaneous auricular vagus nerve stimulation (taVNS), as a non-invasive brain stimulation technique may influence the locus coeruleus-norepinephrine system (LC-NE system) via modulation of the Vagus Nerve (VN) which projects to the LC. Few human studies exist examining the effects of taVNS on the LC-NE system and studies to date assessing the ability of taVNS to target the LC yield heterogeneous results. The aim of this review is to present an overview of the current challenges in assessing effects of taVNS on LC function and how translational approaches spanning animal and human research can help in this regard. A particular emphasis of the review discusses how the effects of taVNS may be influenced by changes in structure and function of the LC-NE system across the human lifespan and in disease.

Keyword(s): Animals (MeSH) ; Humans (MeSH) ; Locus Coeruleus (MeSH) ; Norepinephrine (MeSH) ; Transcutaneous Electric Nerve Stimulation (MeSH) ; Vagus Nerve (MeSH) ; Vagus Nerve Stimulation (MeSH) ; Cross-species translational approach ; Locus coeruleus ; Neurodegeneration ; Neuromodulation ; Noradrenergic system ; Stimulation parameters ; Vagus nerve stimulation ; Norepinephrine

---

Contributing Institute(s):

1. Clinical Neurophysiology and Memory (AG Düzel)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2021

---

Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---