Journal Article (Review Article)

DZNE-2022-00367

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Etiologies of insomnia in Parkinson's disease - Lessons from human studies and animal models.

Mizrahi-Kliger, A. D. ; Feldmann, L. K. ; Kühn, A. A.DZNE* ; Bergman, H.

2022
Academic Press Orlando, Fla.

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Please use a persistent id in citations: doi:10.1016/j.expneurol.2022.113976

Abstract: Sleep disorders are integral to Parkinson's disease (PD). Insomnia, an inability to maintain stable sleep, affects most patients and is widely rated as one of the most debilitating facets of this disease. PD insomnia is often perceived as a multifactorial entity - a consequence of several of the disease symptoms, comorbidities and therapeutic strategies. Yet, this view evolved against a backdrop of a relative scarcity of works trying to directly dissect the underlying neural correlates and mechanisms in animal models. The last years have seen the emergence of a wealth of new evidence regarding the neural underpinnings of insomnia in PD. Here, we review early and recent reports from patients and animal models evaluating the etiology of PD insomnia. We start by outlining the phenomenology of PD insomnia and continue to analyze the evidence supporting insomnia as emanating from four distinct subdivisions of etiologies - the symptoms and comorbidities of the disease, the medical therapy, the degeneration of non-dopaminergic cell groups and subsequent alterations in circadian rhythms, and the degeneration of dopaminergic neurons in the brainstem and its resulting effect on the basal ganglia. Finally, we review emerging neuromodulation-based therapeutic avenues for PD insomnia.

Keyword(s): Animals (MeSH) ; Disease Models, Animal (MeSH) ; Dopaminergic Neurons: pathology (MeSH) ; Humans (MeSH) ; Models, Animal (MeSH) ; Nerve Degeneration (MeSH) ; Parkinson Disease: complications (MeSH) ; Parkinson Disease: physiopathology (MeSH) ; Sleep Initiation and Maintenance Disorders: etiology (MeSH) ; Sleep Initiation and Maintenance Disorders: physiopathology (MeSH) ; Basal ganglia ; Brainstem ; Cortex ; Insomnia ; Neuromodulation ; Parkinson's disease ; Sleep

Note: (CC BY-NC-ND)

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Contributing Institute(s):

1. Coordinator of Clinical Research (AG Endres)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2022

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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