Journal Article

DZNE-2022-00480

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Evolution of disability in spinocerebellar ataxias type 1, 2, 3, and 6.

Jacobi, H. (First author)DZNE* ; Schaprian, T.DZNE* ; Beyersmann, J. ; Tezenas du Montcel, S. ; Schmid, M.DZNE* ; Klockgether, T. (Last author)DZNE* ; EUROSCA ; Groups, R. S. (Collaboration Author)

2022
Wiley Chichester [u.a.]

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Please use a persistent id in citations: doi:10.1002/acn3.51515

Abstract: The aim was to study the evolution of disability in spinocerebellar ataxias (SCAs) type 1, 2, 3, and 6 (SCA1, 2, 3, 6).We analyzed data of two longitudinal cohorts (RISCA, EUROSCA) which recruited ataxic and non-ataxic SCA1, SCA2, SCA3, and SCA6 mutation carriers. To study disability, we used a five-stage system for ataxia defined by walking ability (stages 0-3) and death (stage 4). Transitions were analyzed using a multi-state model with proportional transition hazards. Based on the hazard estimates, transition probabilities and the expected lengths of stay in each stage were calculated. We further studied the effect of sex and CAG repeat length on progression.Data of 3138 visits in 677 participants were analyzed. Median SARA scores for SCA1, SCA2, SCA3, and SCA6 ranged from 1.5 (interquartile range [IQR] = 0.0-3.5) to 3.5 (IQR = 1.4-6.1) in stage 0, 11.5 (IQR = 9.6-14.0) to 13.8 (IQR = 11.0-16.0) in stage 1, 19.0 (IQR = 17.0-21.0) to 23.8 (IQR = 19.5-27.0) in stage 2, and 28.5 (IQR = 26.0-32.5) to 34.0 (IQR = 32.6-37.1) in stage 3. Modeling allowed to calculate the subtype-specific probability to be in a certain stage at a given age and duration of each stage. CAG repeat length was associated with faster progression in SCA1 (HR, 95% CI: 1.1, 1.1-1.2), SCA2 (1.2, 1.1-1.3), and SCA3 (1.1, 1.0-1.2). In SCA6, female sex was associated with faster progression (1.7, 1.1-2.6).Our data are important for counselling of patients, assessment of the relevance of outcome markers, and design of clinical trials.

Keyword(s): Disease Progression (MeSH) ; Female (MeSH) ; Humans (MeSH) ; Spinocerebellar Ataxias: genetics (MeSH)

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Contributing Institute(s):

1. Patient Studies (Patient studies, Bonn)
2. Mathematics, statistics and informatics methods for support of population studies and clinical research (AG Schmid)
3. Clinical Research Coordination (AG Klockgether)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Experiment(s):

1. Registry for Spinocerebellar Ataxies

Appears in the scientific report 2022

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