Journal Article

DZNE-2022-01099

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Functional connectivity maps of theta/alpha and beta coherence within the subthalamic nucleus region.

van Wijk, B. C. M. ; Neumann, W.-J. ; Kroneberg, D. ; Horn, A. ; Irmen, F. ; Sander, T. H. ; Wang, Q. ; Litvak, V. ; Kühn, A. A. (Last author)DZNE*

2022
Academic Press Orlando, Fla.

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Please use a persistent id in citations: doi:10.1016/j.neuroimage.2022.119320

Abstract: The subthalamic nucleus (STN) is a primary target for deep brain stimulation in Parkinson's disease (PD). Although small in size, the STN is commonly partitioned into sensorimotor, cognitive/associative, and limbic subregions based on its structural connectivity profile to cortical areas. We investigated whether such a regional specialization is also supported by functional connectivity between local field potential recordings and simultaneous magnetoencephalography. Using a novel data set of 21 PD patients, we replicated previously reported cortico-STN coherence networks in the theta/alpha and beta frequency ranges, and looked for the spatial distribution of these networks within the STN region. Although theta/alpha and beta coherence peaks were both observed in on-medication recordings from electrode contacts at several locations within and around the STN, sites with theta/alpha coherence peaks were situated at significantly more inferior MNI coordinates than beta coherence peaks. Sites with only theta/alpha coherence peaks, i.e. without distinct beta coherence, were mostly located near the border of sensorimotor and cognitive/associative subregions as defined by a tractography-based atlas of the STN. Peak coherence values were largely unaltered by the medication state of the subject, however, theta/alpha peaks were more often identified in recordings obtained after administration of dopaminergic medication. Our findings suggest the existence of a frequency-specific topography of cortico-STN coherence within the STN, albeit with considerable spatial overlap between functional networks. Consequently, optimization of deep brain stimulation targeting might remain a trade-off between alleviating motor symptoms and avoiding adverse neuropsychiatric side effects.

Keyword(s): Deep Brain Stimulation (MeSH) ; Dopamine Agents (MeSH) ; Humans (MeSH) ; Magnetoencephalography (MeSH) ; Parkinson Disease (MeSH) ; Subthalamic Nucleus (MeSH) ; Deep brain stimulation ; Functional connectivity ; Magnetoencephalography ; Parkinson's disease ; Subthalamic nucleus

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Contributing Institute(s):

1. Coordinator of Clinical Research (AG Endres)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2022

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