Journal Article

DZNE-2022-01173

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Prognostischer und differenzialdiagnostischer Stellenwert der Liquordiagnostik bei neurodegenerativen Demenzerkrankungen.

Haussmann, R.Extern* ; Homeyer, P. ; Brandt, D. M.DZNE* ; Donix, M. (Last author)DZNE*

2022
Springer Heidelberg

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Please use a persistent id in citations: doi:10.1007/s00115-022-01339-6

Abstract: Cerebrospinal fluid (CSF) analysis is an important diagnostic tool in the assessment of dementia. For the differentiation of Alzheimer's disease from other etiologies of dementia syndromes, established biological markers could be helpful to confirm a distinctive neuropathology. Whereas negative CSF findings can rule out the majority of primarily neurodegenerative disorders, overlapping biomarker profiles remain a diagnostic challenge. Therefore, it is important to interpret CSF results within a specific clinical context. Furthermore, atypical CSF data can be challenging and require profound knowledge of preanalytics, biomarker profiles and the broad spectrum of diseases associated with cognitive decline. Beyond the Alzheimer's disease clinical spectrum, current studies aim at investigating CSF biomarkers to better differentiate tauopathies, TDP43(Transactive response DNA binding protein 43 kDa)-proteinopathies and synucleinopathies.

Keyword(s): Humans (MeSH) ; Alzheimer Disease: diagnosis (MeSH) ; tau Proteins: cerebrospinal fluid (MeSH) ; Prognosis (MeSH) ; Neurodegenerative Diseases: diagnosis (MeSH) ; Biomarkers: cerebrospinal fluid (MeSH) ; Amyloid beta-Peptides: cerebrospinal fluid (MeSH) ; Alzheimer’s disease ; Cerebrospinal fluid analysis ; Frontotemporal dementia ; Lewy body dementia ; Neurodegenerative disease

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Contributing Institute(s):

1. Clinical Study Team Dresden (Clinical Study Team Dresden ; AG Falkenburger)
2. Clinical planning and intersite group (AG Donix)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2022

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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