Journal Article

DZNE-2022-01177

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png A translational perspective on pathophysiological changes of oscillatory activity in dystonia and parkinsonism

Rauschenberger, L. ; Güttler, C. ; Volkmann, J. ; Kühn, A.DZNE* ; Ip, C. W. ; Lofredi, R.

2022
Academic Press Orlando, Fla.

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Please use a persistent id in citations: doi:10.1016/j.expneurol.2022.114140

Abstract: Intracerebral recordings from movement disorders patients undergoing deep brain stimulation have allowed the identification of pathophysiological patterns in oscillatory activity that correlate with symptom severity. Changes in oscillatory synchrony occur within and across brain areas, matching the classification of movement disorders as network disorders. However, the underlying mechanisms of oscillatory changes are difficult to assess in patients, as experimental interventions are technically limited and ethically problematic. This is why animal models play an important role in neurophysiological research of movement disorders. In this review, we highlight the contributions of translational research to the mechanistic understanding of pathological changes in oscillatory activity, with a focus on parkinsonism and dystonia, while addressing the limitations of current findings and proposing possible future directions.

Keyword(s): Animals (MeSH) ; Deep Brain Stimulation (MeSH) ; Dystonia: therapy (MeSH) ; Dystonic Disorders (MeSH) ; Movement Disorders: pathology (MeSH) ; Parkinsonian Disorders (MeSH)

Note: CC BY-NC-ND: https://creativecommons.org/licenses/by-nc-nd/4.0/

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Contributing Institute(s):

1. Coordinator of Clinical Research (AG Endres)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2022

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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