Journal Article

DZNE-2022-01310

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Spectral and spatial distribution of subthalamic beta peak activity in Parkinson's disease patients.

Darcy, N. ; Lofredi, R. ; Al-Fatly, B. ; Neumann, W.-J. ; Hübl, J. ; Brücke, C. ; Krause, P. ; Schneider, G.-H. ; Kühn, A. (Last author)DZNE*

2022
Academic Press Orlando, Fla.

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Please use a persistent id in citations: doi:10.1016/j.expneurol.2022.114150

Abstract: Current efforts to optimise subthalamic deep brain stimulation in Parkinson's disease patients aim to harness local oscillatory activity in the beta frequency range (13-35 Hz) as a feedback-signal for demand-based adaptive stimulation paradigms. A high prevalence of beta peak activity is prerequisite for this approach to become routine clinical practice. In a large dataset of postoperative rest recordings from 106 patients we quantified occurrence and identified determinants of spectral peaks in the alpha, low and high beta bands. At least one peak in beta band occurred in 92% of patients and 84% of hemispheres off medication, irrespective of demographic parameters, clinical subtype or motor symptom severity. Distance to previously described clinical sweet spot was significantly related both to beta peak occurrence and to spectral power (rho -0.21, p 0.006), particularly in the high beta band. Electrophysiological landscapes of our cohort's dataset in normalised space showed divergent heatmaps for alpha and beta but found similar regions for low and high beta frequency bands. We discuss potential ramifications for clinicians' programming decisions. In summary, this report provides robust evidence that spectral peaks in beta frequency range can be detected in the vast majority of Parkinsonian subthalamic nuclei, increasing confidence in the broad applicability of beta-guided deep brain stimulation.

Keyword(s): Beta Rhythm: physiology (MeSH) ; Deep Brain Stimulation (MeSH) ; Humans (MeSH) ; Parkinson Disease: drug therapy (MeSH) ; Subthalamic Nucleus (MeSH) ; Adaptive DBS ; DBS ; Deep brain stimulation ; Parkinson's disease ; STN ; beta activity ; beta peak

Note: CC BY-NC-ND

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Contributing Institute(s):

1. Coordinator of Clinical Research (AG Endres)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2022

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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