Journal Article

DZNE-2022-01591

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Disentangling the relationship of subjective cognitive decline and depressive symptoms in the development of cognitive decline and dementia

Kleineidam, L. (First author)DZNE* ; Wagner, M.DZNE* ; Guski, J. ; Wolfsgruber, S.DZNE* ; Miebach, L.DZNE* ; Bickel, H. ; König, H.-H. ; Weyerer, S. ; Lühmann, D. ; Kaduszkiewicz, H. ; Luppa, M. ; Röhr, S. ; Pentzek, M. ; Wiese, B. ; Maier, W.Extern* ; Scherer, M. ; Kornhuber, J. ; Peters, O.DZNE* ; Frölich, L.Extern* ; Wiltfang, J.DZNE* ; Lewczuk, P. ; Hüll, M. ; Ramirez, A.DZNE* ; Jessen, F.DZNE* ; Riedel-Heller, S. G. ; Heser, K.Extern*

2023
Wiley Hoboken, NJ

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Please use a persistent id in citations: doi:10.1002/alz.12785

Abstract: Subjective cognitive decline (SCD) and depressive symptoms (DS) frequently co-occur prior to dementia. However, the temporal sequence of their emergence and their combined prognostic value for cognitive decline and dementia is unclear.Temporal relationships of SCD, DS and memory decline were examined by latent difference score modeling in a high-aged, population-based cohort (N = 3217) and validated using Cox-regression of dementia-conversion. In 334 cognitively unimpaired SCD-patients from memory-clinics, we examined the association of DS with cognitive decline and with cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers.In the population-based cohort, SCD preceded DS. High DS were associated with increased risk of dementia conversion in individuals with SCD. In SCD-patients from memory-clinics, high DS were associated with greater cognitive decline. CSF Aß42 predicted increasing DS.SCD typically precedes DS in the evolution to dementia. SCD-patients from memory-clinics with DS may constitute a high-risk group for cognitive decline.Subjective cognitive decline (SCD) precedes depressive symptoms (DS) as memory declines. Emerging or persistent DS after SCD reports predict dementia. In SCD patients, more amyloid pathology relates to increasing DS. SCD patients with DS are at high risk for symptomatic progression.

Keyword(s): Humans (MeSH) ; Aged (MeSH) ; Depression (MeSH) ; Alzheimer Disease: diagnosis (MeSH) ; Cognitive Dysfunction: diagnosis (MeSH) ; Biomarkers: cerebrospinal fluid (MeSH) ; Amyloid beta-Peptides: cerebrospinal fluid (MeSH) ; Biomarkers ; Alzheimer's disease ; depression ; latent difference score model ; subjective cognitive decline ; temporal sequence ; Amyloid beta-Peptides

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Contributing Institute(s):

1. Neuropsychology (AG Wagner)
2. Clinical Research Coordination (Clinical Research (Bonn))
3. Molecular biomarkers for predictive diagnostics of neurodegenerative diseases (AG Wiltfang)
4. Clinical Dementia Research (Rostock /Greifswald) (AG Teipel)
5. Interdisciplinary Dementia Research (AG Endres)
6. Patient Studies (Bonn) (Patient Studies (Bonn))
7. Clinical Alzheimer’s Disease Research (AG Jessen)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2023

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Wiley ; Essential Science Indicators ; IF >= 10 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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