Dataset

DZNE-2022-01784

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Dataset: Minor neuropsychological deficits in patients with subjective cognitive decline

Wolfsgruber, S. (First author)DZNE* ; Kleineidam, L.DZNE* ; Guski, J.DZNE* ; Polcher, A.DZNE* ; Frommann, I.DZNE* ; Roeske, S.DZNE* ; Spruth, E. J.Extern* ; Franke, C. ; Priller, J.Extern* ; Kilimann, I.DZNE* ; Teipel, S.DZNE* ; Bürger, K.DZNE* ; Janowitz, D.DZNE* ; Laske, C.DZNE* ; Buchmann, M.DZNE* ; Peters, O.DZNE* ; Menne, F.DZNE* ; Fuentes Casan, M.DZNE* ; Wiltfang, J.Extern* ; Bartels, C.Extern* ; Düzel, E.DZNE* ; Metzger, C.DZNE* ; Glanz, W.Extern* ; Thelen, M.DZNE* ; Spottke, A.DZNE* ; Ramirez, A.DZNE* ; Kofler, B.DZNE* ; Fließbach, K.DZNE* ; Schneider, A.DZNE* ; Heneka, M.DZNE* ; Brosseron, F.DZNE* ; Meiberth, D.DZNE* ; Jessen, F.DZNE* ; Wagner, M. (Last author)DZNE*

2019
Dryad

This record in other databases:  

Please use a persistent id in citations: doi:10.5061/DRYAD.PG4F4QRJP  doi:10.5061/dryad.pg4f4qrjp

Abstract: Objective: To determine the nature and extent of minor neuropsychological deficits in patients with subjective cognitive decline (SCD) and their association with cerebrospinal fluid (CSF) biomarkers of Alzheimer’s disease (AD). Method: We analyzed data from n=449 cognitively normal participants (n=209 healthy controls, n=240 SCD patients) from an interim data release of the German Center for Neurodegenerative Diseases Longitudinal Cognitive Impairment and Dementia Study (DELCODE). An extensive neuropsychological test battery was applied at baseline for which we established a latent, five cognitive domain factor structure comprising learning & memory, executive functions, language abilities, working memory and visuospatial functions. We compared groups regarding global and domain-specific performance and correlated performance with different CSF markers of AD pathology. Results: We observed worse performance (Cohen’s d≈0.25-0.5, adjusted for age-, sex differences with ANCOVA) in global performance, memory, executive functions and language abilities for the SCD group compared to healthy controls. In addition, worse performance in these domains was moderately (r≈0.3) associated with lower CSF-Aβ42/40 and CSF-Aβ42/ptau181 in the whole sample and specifically in the SCD subgroup. Conclusions: Within the spectrum of clinically unimpaired (i.e., “pre- mild cognitive impairment”) cognitive performance, SCD is associated with minor deficits in memory, executive function and language abilities. The association of these subtle cognitive deficits with AD CSF biomarkers speaks to their validity and potential use for the early detection of underlying preclinical AD.

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Contributing Institute(s):

1. Neuropsychology (AG Wagner)
2. Clinical Dementia Research (Rostock /Greifswald) (AG Teipel)
3. Vascular Cognitive Impairment & Post-Stroke Dementia (AG Dichgans)
4. Parkinson Genetics (AG Gasser)
5. Vascular Pathology (AG Dirnagl)
6. Interdisciplinary Dementia Research (AG Endres)
7. Microcircuits of Memory (AG Brecht)
8. Clinical Research Platform (CRP) (Clinical Research Platform (CRP))
9. Patient Studies Bonn (Patient Studies Bonn)
10. Translational Dementia Research (Bonn) (AG Schneider)
11. Interventional Trials and Biomarkers in Neurodegenerative Diseases (Biomarker)
12. Clinical Alzheimer’s Disease Research (AG Jessen)
13. Delcode (Delcode)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)
2. 352 - Disease Mechanisms (POF4-352) (POF4-352)
3. 351 - Brain Function (POF4-351) (POF4-351)

Experiment(s):

1. Longitudinal Cognitive Impairment and Dementia Study

Appears in the scientific report 2019

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Linked articles:

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Journal Article Wolfsgruber, S.DZNE* ; Kleineidam, L.DZNE* ; Guski, J. ; Polcher, A.DZNE* ; Frommann, I.DZNE* ; Roeske, S.DZNE* ; Spruth, E. J. ; Franke, C. ; Priller, J. ; Kilimann, I.DZNE* ; Teipel, S.DZNE* ; Buerger, K. ; Janowitz, D. ; Laske, C. ; Buchmann, M. ; Peters, O. ; Menne, F. ; Fuentes Casan, M. ; Wiltfang, J. ; Bartels, C.DZNE* ; Düzel, E. ; Metzger, C. ; Glanz, W. ; Thelen, M.DZNE* ; Spottke, A.DZNE* ; Ramirez, A.DZNE* ; Kofler, B.DZNE* ; Fließbach, K.DZNE* ; Schneider, A.DZNE* ; Heneka, M. T.DZNE* ; Brosseron, F.DZNE* ; Meiberth, D.DZNE* ; Jessen, F.DZNE* ; Wagner, M. (Last author)DZNE*
Minor neuropsychological deficits in patients with subjective cognitive decline
Neurology 95(9), e1134 - e1143 (2020) [10.1212/WNL.0000000000010142]2020 BibTeX | EndNote: XML, Text | RIS

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