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Analysis of Psychological Symptoms Following Disclosure of Amyloid-Positron Emission Tomography Imaging Results to Adults With Subjective Cognitive Decline.
Caprioglio, C. ; Ribaldi, F. ; Visser, L. N. C. ; Minguillon, C. ; Collij, L. E. ; Grau-Rivera, O. ; Zeyen, P. ; Molinuevo, J. L. ; Gispert, J. D. ; Garibotto, V. ; Moro, C. ; Walker, Z. ; Edison, P. ; Demonet, J.-F. ; Barkhof, F. ; Scheltens, P. ; Alves, I. L. ; Gismondi, R. ; Farrar, G. ; Stephens, A. W. ; Jessen, F.DZNE* ; Frisoni, G. B. ; Altomare, D. ; consortium, A. (Collaboration Author) ; Abdelnour, C. (Contributor) ; Aguilera, N. (Contributor) ; Aksman, L. (Contributor) ; Alarcón-Martín, E. (Contributor) ; Alegret, M. (Contributor) ; Alonso-Lana, S. (Contributor) ; Altomare, D. (Contributor) ; Andersen, P. (Contributor) ; Arab, M. (Contributor) ; Aspö, M. (Contributor) ; Bader, I. (Contributor) ; Bader, I. (Contributor) ; Banton, N. (Contributor) ; Barkhof, F. (Contributor) ; Barnes, R. (Contributor) ; Barrie, D. (Contributor) ; Battle, M. (Contributor) ; Belén Collado, A. (Contributor) ; Bellet, J. (Contributor) ; Berkhof, J. (Contributor) ; Biger, M. (Contributor) ; Birck, C. (Contributor) ; Bischof, G. (Contributor) ; Boada, M. (Contributor) ; Boellaard, R. (Contributor) ; Bogdanovic, N. (Contributor) ; Bollack, A. (Contributor) ; Bombois, S. (Contributor) ; Borg, S. (Contributor) ; Borjesson-Hanson, A. (Contributor) ; Boskov, V. (Contributor) ; Boutantin, J. (Contributor) ; Boutoleau-Bretonniere, C. (Contributor) ; Bouwman, F. (Contributor) ; Breuilh, L. (Contributor) ; Bringman, E. (Contributor) ; Brunel, B. (Contributor) ; Bucci, M. (Contributor) ; Buckley, C. (Contributor) ; Buendía, M. (Contributor) ; Bullich, S. (Contributor) ; Calvet, A. (Contributor) ; Cañada, L. (Contributor) ; Cañada, M. (Contributor) ; Caprioglio, C. (Contributor) ; Cardoso, J. (Contributor) ; Carlier, J. (Contributor) ; Carre, E. (Contributor) ; Carrie, I. (Contributor) ; Cassagnaud, P. (Contributor) ; Cassol, E. (Contributor) ; Castilla-Martí, M. (Contributor) ; Cazalon, E. (Contributor) ; Chaarriau, T. (Contributor) ; Chaigeau, R. (Contributor) ; Chalmers, T. (Contributor) ; Clerc, M.-T. (Contributor) ; Clerigue, M. (Contributor) ; Cognat, E. (Contributor) ; Coll, N. (Contributor) ; Collij, L. E. (Contributor) ; Connely, P. (Contributor) ; Cordier, E. (Contributor) ; Costes, C. (Contributor) ; Coulange, C. (Contributor) ; Courtemanche, H. (Contributor) ; Creisson, E. (Contributor) ; Crinquette, C. (Contributor) ; Cuevas, R. (Contributor) ; Cufi, M.-N. (Contributor) ; Dardenne, S. (Contributor) ; de Arriba, M. (Contributor) ; de Costa Luis, C. (Contributor) ; de Gier, Y. (Contributor) ; de Verbizier Lonjon, D. (Contributor) ; Dekker, V. (Contributor) ; Dekyndt, B. (Contributor) ; Delbeuck, X. (Contributor) ; Delrieu, J. (Contributor) ; Demonet, J.-F. (Contributor) ; Deramecourt, V. (Contributor) ; Desclaux, F. (Contributor) ; Diaz, C. (Contributor) ; Diego, S. (Contributor) ; Djafar, M. (Contributor) ; Dölle, B. (Contributor) ; Doull, L. (Contributor) ; Dricot, L. (Contributor) ; Drzezga, A. (Contributor)Extern* ; Dubois, B. (Contributor) ; Dumont, J. (Contributor) ; Dumur, J. (Contributor) ; Dumurgier, J. (Contributor) ; Dvorak, M. (Contributor) ; Ecay, M. (Contributor) ; Edison, P. (Contributor) ; Escher, C. (Contributor)Extern* ; Estanga, A. (Contributor) ; Esteban, E. (Contributor) ; Fanjaud, G. (Contributor) ; Farrar, G. (Contributor) ; Fauria, K. (Contributor) ; Felez Sanchez, M. (Contributor) ; Feukam Talla, P. (Contributor) ; Ford, L. (Contributor) ; Frisoni, G. B. (Contributor) ; Fuster, D. (Contributor) ; Gabelle, A. (Contributor) ; Garibotto, V. (Contributor) ; Gaubert, S. (Contributor) ; Gauci, C. (Contributor) ; Geldhof, C. (Contributor) ; Georges, J. (Contributor) ; Ghika, J. (Contributor) ; Gismondi, R. (Contributor) ; Gispert, J. D. (Contributor) ; González, E. (Contributor) ; Goovaerts, V. (Contributor) ; Goulart, D. M. (Contributor) ; Grasselli, C. (Contributor) ; Grau-Rivera, O. (Contributor) ; Gray, K. (Contributor) ; Greensmith, M. (Contributor) ; Grozn, L. (Contributor) ; Guillemaud, C. (Contributor) ; Gunn, F. (Contributor) ; Guntur Ramkumar, P. (Contributor) ; Hagman, G. (Contributor) ; Hansseuw, B. (Contributor) ; Heeman, F. (Contributor) ; Hendriks, J. (Contributor) ; Himmelmann, J. (Contributor) ; Hitzel, A. (Contributor) ; Hives, F. (Contributor) ; Hoenig, M. (Contributor) ; Hourrègue, C. (Contributor) ; Hudson, J. (Contributor) ; Huguet, J. (Contributor) ; Ibarria, M. (Contributor) ; Iidow, I. (Contributor) ; Indart, S. (Contributor) ; Ingala, S. (Contributor) ; Ivanoiu, A. (Contributor) ; Jacquemont, C. (Contributor) ; Jelic, V. (Contributor) ; Jessen, F. (Contributor)Extern* ; Jiao, J. (Contributor) ; Jofresa, S. (Contributor) ; Jonsson, C. (Contributor) ; Kaliukhovich, D. (Contributor) ; Kern, S. (Contributor) ; Kivipelto, M. (Contributor) ; Knezevic, I. (Contributor) ; Kuchcinski, G. (Contributor) ; Laforce, M. (Contributor) ; Lafuente, A. (Contributor) ; Lala, F. (Contributor) ; Lammertsma, A. (Contributor) ; Lax, M. (Contributor) ; Lebouvier, T. (Contributor) ; Lee, H.-Y. (Contributor) ; Lee, L. (Contributor) ; Leeuwis, A. (Contributor) ; Lefort, A. (Contributor) ; Legrand, J.-F. (Contributor) ; Leroy, M. (Contributor) ; Lesoil Markowski, C. (Contributor) ; Levy, M. (Contributor) ; Lhommel, R. (Contributor) ; Lopes, R. (Contributor) ; Lopes Alves, I. (Contributor) ; Lorenzini, L. (Contributor) ; Lorette, A. (Contributor) ; Luckett, E. (Contributor) ; Lundin, M. (Contributor) ; Mackowiak, M.-A. (Contributor) ; Malotaux, V. (Contributor) ; Manber, R. (Contributor) ; Manyakov, N. (Contributor) ; Markiewicz, P. (Contributor) ; Marne, P. (Contributor) ; Marquié, M. (Contributor) ; Martín, E. (Contributor) ; Martínez, J. (Contributor) ; Martinez Lage, P. (Contributor) ; Mastenbroek, S. E. (Contributor) ; Maureille, A. (Contributor) ; Meersmans, K. (Contributor) ; Mett, A. (Contributor) ; Milne, J. (Contributor) ; Minguillón, C. (Contributor) ; Modat, M. (Contributor) ; Molinuevo, J. L. (Contributor) ; Montrreal, L. (Contributor) ; Moro, C. (Contributor) ; Müller, T. (Contributor) ; Muniz, G. (Contributor) ; Mutsarts, H. J. (Contributor) ; Nilsson, T. (Contributor) ; Ninerola, A. (Contributor) ; Nordberg, A. (Contributor) ; Novaes, W. (Contributor) ; Nuno Carmelo Pires Silva, J. (Contributor) ; Operto, G. (Contributor) ; Orellana, A. (Contributor) ; Ousset, P.-J. (Contributor) ; Outteryck, O. (Contributor) ; Pallardy, A. (Contributor) ; Palombit, A. (Contributor) ; Pancho, A. (Contributor) ; Pappon, M. (Contributor) ; Paquet, C. (Contributor) ; Pariente, J. (Contributor) ; Pasquier, F. (Contributor) ; Payoux, P. (Contributor) ; Peaker, H. (Contributor) ; Pelejà, E. (Contributor) ; Pennetier, D. (Contributor) ; Pérez-Cordón, A. (Contributor) ; Perissinotti, A. (Contributor) ; Perrenoud, M. P. (Contributor) ; Petit, S. (Contributor) ; Petyt, G. (Contributor) ; Pfeil, J. (Contributor) ; Pirotte, B. (Contributor) ; Pla, S. (Contributor) ; Plaza Wuthrich, S. (Contributor) ; Poitrine, L. (Contributor) ; Pollet, M. (Contributor) ; Poncelet, J.-B. (Contributor) ; Prior, J. (Contributor) ; Pruvo, J.-P. (Contributor) ; Putallaz, P. (Contributor) ; Queneau, M. (Contributor) ; Quenon, L. (Contributor) ; Rădoi, A. (Contributor) ; Rafiq, M. (Contributor) ; Ramage, F. (Contributor) ; Ramis, M. (Contributor) ; Reinwald, M. (Contributor) ; Rios, G. (Contributor) ; Ritchie, C. (Contributor) ; Rodriguez, E. (Contributor) ; Rollin, A. (Contributor) ; Rouaud, O. (Contributor) ; Sacuiu, S. (Contributor) ; Saint-Aubert, L. (Contributor) ; Sala, A. (Contributor) ; Salabert, A.-S. (Contributor) ; Saldias, J. (Contributor) ; Salvadó, G. (Contributor) ; Sanabria, A. (Contributor) ; Sannemann, L. (Contributor) ; Sastre, N. (Contributor) ; Savina, D. (Contributor) ; Savitcheva, I. (Contributor) ; Schaeverbeke, J. (Contributor) ; Scheltens, P. (Contributor) ; Schildermans, C. (Contributor) ; Schmidt, M. (Contributor) ; Schöll, M. (Contributor) ; Schuermans, J. (Contributor) ; Semah, F. (Contributor) ; Shekari, M. (Contributor) ; Skoog, I. (Contributor) ; Sotolongo-Grau, O. (Contributor) ; Stephens, A. (Contributor) ; Stewart, T. (Contributor) ; Stutzmann, J. (Contributor) ; Tait, M. (Contributor) ; Tárraga, L. (Contributor) ; Tartari, J. P. (Contributor) ; Tysen-Backstrom, A.-C. (Contributor) ; Valero, S. (Contributor) ; Vallez Garcia, D. (Contributor) ; van Berckel, B. N. M. (Contributor) ; van Essen, M. (Contributor) ; Van Laere, K. (Contributor) ; van Leur, J. (Contributor) ; van Maurik, I. S. (Contributor) ; Vandenberghe, R. (Contributor) ; Vellas, B. (Contributor) ; Virolinen, J. (Contributor) ; Visser, P. J. (Contributor) ; Walker, Z. (Contributor) ; Walles, H. (Contributor) ; Wallin, E. (Contributor) ; Whitelaw, G. (Contributor) ; Wimberley, C. (Contributor) ; Win, Z. (Contributor) ; Wink, A. M. (Contributor) ; Wolz, R. (Contributor) ; Woodside, J. (Contributor) ; Yaqub, M. (Contributor) ; Zettergren, A. (Contributor) ; Zeyen, P. (Contributor)
2023
American Medical Association
Chicago, Ill.
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Please use a persistent id in citations: doi:10.1001/jamanetworkopen.2022.50921
Abstract: Individuals who are amyloid-positive with subjective cognitive decline and clinical features increasing the likelihood of preclinical Alzheimer disease (SCD+) are at higher risk of developing dementia. Some individuals with SCD+ undergo amyloid-positron emission tomography (PET) as part of research studies and frequently wish to know their amyloid status; however, the disclosure of a positive amyloid-PET result might have psychological risks.To assess the psychological outcomes of the amyloid-PET result disclosure in individuals with SCD+ and explore which variables are associated with a safer disclosure in individuals who are amyloid positive.This prospective, multicenter study was conducted as part of The Amyloid Imaging to Prevent Alzheimer Disease Diagnostic and Patient Management Study (AMYPAD-DPMS) (recruitment period: from April 2018 to October 2020). The setting was 5 European memory clinics, and participants included patients with SCD+ who underwent amyloid-PET. Statistical analysis was performed from July to October 2022.Disclosure of amyloid-PET result.Psychological outcomes were defined as (1) disclosure related distress, assessed using the Impact of Event Scale-Revised (IES-R; scores of at least 33 indicate probable presence of posttraumatic stress disorder [PTSD]); and (2) anxiety and depression, assessed using the Hospital Anxiety and Depression scale (HADS; scores of at least 15 indicate probable presence of severe mood disorder symptoms).After disclosure, 27 patients with amyloid-positive SCD+ (median [IQR] age, 70 [66-74] years; gender: 14 men [52%]; median [IQR] education: 15 [13 to 17] years, median [IQR] Mini-Mental State Examination [MMSE] score, 29 [28 to 30]) had higher median (IQR) IES-R total score (10 [2 to 14] vs 0 [0 to 2]; P < .001), IES-R avoidance (0.00 [0.00 to 0.69] vs 0.00 [0.00 to 0.00]; P < .001), IES-R intrusions (0.50 [0.13 to 0.75] vs 0.00 [0.00 to 0.25]; P < .001), and IES-R hyperarousal (0.33 [0.00 to 0.67] vs 0.00 [0.00 to 0.00]; P < .001) scores than the 78 patients who were amyloid-negative (median [IQR], age, 67 [64 to 74] years, 45 men [58%], median [IQR] education: 15 [12 to 17] years, median [IQR] MMSE score: 29 [28 to 30]). There were no observed differences between amyloid-positive and amyloid-negative patients in the median (IQR) HADS Anxiety (-1.0 [-3.0 to 1.8] vs -2.0 [-4.8 to 1.0]; P = .06) and Depression (-1.0 [-2.0 to 0.0] vs -1.0 [-3.0 to 0.0]; P = .46) deltas (score after disclosure - scores at baseline). In patients with amyloid-positive SCD+, despite the small sample size, higher education was associated with lower disclosure-related distress (ρ = -0.43; P = .02) whereas the presence of study partner was associated with higher disclosure-related distress (W = 7.5; P = .03). No participants with amyloid-positive SCD+ showed probable presence of PTSD or severe anxiety or depression symptoms at follow-up.The disclosure of a positive amyloid-PET result to patients with SCD+ was associated with a bigger psychological change, yet such change did not reach the threshold for clinical concern.
Keyword(s): Male (MeSH) ; Humans (MeSH) ; Adult (MeSH) ; Aged (MeSH) ; Alzheimer Disease: diagnosis (MeSH) ; Brain: metabolism (MeSH) ; Amyloid beta-Peptides: metabolism (MeSH) ; Prospective Studies (MeSH) ; Disclosure (MeSH) ; Positron-Emission Tomography (MeSH) ; Cognitive Dysfunction: diagnostic imaging (MeSH) ; Amyloid beta-Peptides
Contributing Institute(s):
- Clinical Alzheimer’s Disease Research (AG Jessen)
Research Program(s):
- 353 - Clinical and Health Care Research (POF4-353) (POF4-353)
Appears in the scientific report
2023
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