Journal Article

DZNE-2023-00773

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Ageing-associated phenotypes in mice

Xie, K. (First author)DZNE* ; Ehninger, D. (Last author)DZNE*

2023
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.mad.2023.111852

Abstract: Ageing is a continuous process in life featuring progressive damage accumulation that leads to physiological decline, functional deterioration and ultimately death of an organism. Based on the relatively close anatomical and physiological similarity to humans, the mouse has been proven as a valuable model organism in ageing research over the last decades. In this review, we survey methods and tools currently in use to assess ageing phenotypes in mice. We summarize a range of ageing-associated alterations detectable at two major levels of analysis: (1) physiology and pathophysiology and (2) molecular biomarkers. Age-sensitive phenotypes provided in this article may serve to inform future studies targeting various aspects of organismal ageing in mice. In addition, we discuss conceptual and technical challenges faced by previous ageing studies in mice and, where possible, provide recommendations on how to resolve some of these issues. © 2023 Elsevier B.V.

Keyword(s): Humans (MeSH) ; Mice (MeSH) ; Animals (MeSH) ; Aging: physiology (MeSH) ; Biomarkers (MeSH) ; Phenotype (MeSH) ; Ageing ; Biology ; Lifespan ; Mouse ; Phenotypes ; Biomarkers

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Contributing Institute(s):

1. Translational Biogerontology (AG Ehninger)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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