guest ::
| Home > Publications Database > Uncovering the Molecular Link Between Lead Toxicity and Parkinson's Disease. |
| Home > Publications Database > Uncovering the Molecular Link Between Lead Toxicity and Parkinson's Disease. |
| Journal Article (Review Article) | DZNE-2023-00802 |
; ;
2023
Liebert
Larchmont, NY
This record in other databases: 
Please use a persistent id in citations: doi:10.1089/ars.2022.0076
Abstract: Significance: Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects millions around the world. The etiology of PD remains unknown, but environmental and occupational exposures to heavy metals are likely at play, and may impact the severity of the disease. Lead is a toxin known to affect many organs in the body throughout life, particularly the central nervous system. Recent Advances: In this study, we summarize and examine the evidence for such environmental and/or occupational exposures, with a focus on the molecular mechanisms associated with lead exposure and its potential contribution to the onset of parkinsonism in PD. In particular, populational studies suggest higher bone and blood lead levels are associated with increased risk of PD. Interestingly, low levels of lead exposure in the very early stages of life cause increase the production of alpha-synuclein protein in animal models. Critical Issues: Although the specific mechanisms underlying this association have not been fully assessed, oxidative stress and mitochondrial dysfunction are likely implicated and may explain the toxic effects that connect lead exposure to parkinsonism. Future Directions: Additional pre-clinical and clinical studies should be performed in order to further document the molecular link between lead toxicity and PD, as this may open novel perspectives in terms of disease prevention. Antioxid. Redox Signal. 39, 321-335.
Keyword(s): Animals (MeSH) ; Parkinson Disease: etiology (MeSH) ; Parkinson Disease: metabolism (MeSH) ; Lead: toxicity (MeSH) ; Parkinsonian Disorders: complications (MeSH) ; Central Nervous System: metabolism (MeSH) ; Models, Animal (MeSH) ; Parkinson's disease ; environmental factors ; heavy metals ; lead ; oxidative stress ; Lead
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 5 ; JCR ; Nationallizenz
; PubMed Central ; SCOPUS ; Web of Science Core Collection
|
The record appears in these collections: |