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| Home > Publications Database > Dataset: Whole genome transcriptome data from the retrosplenial cortex and hippocampus of female and male control and APP/PS1 Alzheimer’s disease mice. |
| Home > Publications Database > Dataset: Whole genome transcriptome data from the retrosplenial cortex and hippocampus of female and male control and APP/PS1 Alzheimer’s disease mice. |
| Dataset | DZNE-2023-00970 |
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2023
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Please use a persistent id in citations: doi:10.17632/Z9264694B4.2 doi:10.17632/z9264694b4.2
Abstract: The uploaded transcriptome data were obtained from APPswePS1dE9 transgenic mice with a C57BL/6J background (APPPS1) and related control animals. The APPPS1 Alzheimer mouse line carries a human APP with Swedish double mutation (APPswe) cointegrated with human PS1 with exon 9 deletion (PS1dE). The mutant mice (B6.Cg-Tg(APPswe, PSEN1dE9)85Dbo/Mmjax, MMRRC stock no. 34832-JAX) and their wildtype littermates were purchased from Jackson Laboratory. In total, eight control animals (four ♂, age: 32.72 ± 0.38 weeks; four ♀, age: 32.14 ± 0.25 weeks) and eight APPswePS1dE mice (three ♂, age: 32.81 ± 0.24 weeks; five ♀, age: 32.66 ± 0.39 weeks) were used for hippocampal and cortical extirpation and subsequent transcriptome analysis. Importantly, both sexes were used and analyzed. Note that the experimental animals were labeled in the dataset as follows:Four male control mice: Control #1, Control #2, Control #3, Control #4 (note that for Control #4 no transcriptome data from the RS cortex were obtained)Four female control mice: Control #5, Control #6, Control #7, Control #8Three male APPPS1 mice: APPPS1 #1, APPPS1 #2, APPPS1 #3Five male APPPS1 mice: APPPS1 #4, APPPS1 #5, APPPS1 #6, APPPS1 #7, APPPS1 #8 (note that for APP/PS1 #8 no transcriptome data from the hippocampus were obtained)All experimental mice were housed in groups of 3-4 in clear Makrolon cages type II with ad libitum access to drinking water and standard food pellets. Mice were maintained at an ambient temperature of 21 ± 2°C, 50–60% relative humidity, and on a conventional 12 h/12 h light/dark cycle beginning at 5:00 am using ventilated cabinets (Model 9AV125P, (Tecniplast, Germany). All animals were strictly adapted to the circadian pattern preceding subsequent cortical and hippocampal extirpation and RNA isolation.
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Journal Article
Whole genome transcriptome data from the WT cortex and hippocampus of female and male control and APP/PS1 Alzheimer's disease mice.
Data in Brief 50, 109594 (2023) [10.1016/j.dib.2023.109594]
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