Journal Article (Review Article)

DZNE-2024-00092

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Current Technologies Unraveling the Significance of Post-Translational Modifications (PTMs) as Crucial Players in Neurodegeneration.

Zafar, S. (First author) ; Fatima, S. I.DZNE* ; Schmitz, M.DZNE* ; Zerr, I. (Last author)DZNE*

2024
MDPI Basel

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Please use a persistent id in citations: doi:10.3390/biom14010118

Abstract: Neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease, and Huntington's disease, are identified and characterized by the progressive loss of neurons and neuronal dysfunction, resulting in cognitive and motor impairment. Recent research has shown the importance of PTMs, such as phosphorylation, acetylation, methylation, ubiquitination, sumoylation, nitration, truncation, O-GlcNAcylation, and hydroxylation, in the progression of neurodegenerative disorders. PTMs can alter protein structure and function, affecting protein stability, localization, interactions, and enzymatic activity. Aberrant PTMs can lead to protein misfolding and aggregation, impaired degradation, and clearance, and ultimately, to neuronal dysfunction and death. The main objective of this review is to provide an overview of the PTMs involved in neurodegeneration, their underlying mechanisms, methods to isolate PTMs, and the potential therapeutic targets for these disorders. The PTMs discussed in this article include tau phosphorylation, α-synuclein and Huntingtin ubiquitination, histone acetylation and methylation, and RNA modifications. Understanding the role of PTMs in neurodegenerative diseases may provide new therapeutic strategies for these devastating disorders.

Keyword(s): Humans (MeSH) ; Protein Processing, Post-Translational (MeSH) ; Phosphorylation (MeSH) ; Ubiquitination (MeSH) ; Acetylation (MeSH) ; Alzheimer Disease (MeSH) ; Alzheimer’s disease ; Alzheimer’s disease ; Alzheimer’s disease ; PTM ; Parkinson’s disease ; neuronal dysfunction ; proteomics ; synuclein ; tau phosphorylation ; Parkinson’s disease ; Parkinson’s disease

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Contributing Institute(s):

1. Translational Studies and Biomarker (AG Zerr)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2024

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Database coverage:
; ; ; ; Article Processing Charges ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Ebsco Academic Search ; Essential Science Indicators ; Fees ; IF >= 5 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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