guest ::
| Home > Publications Database > Evaluating the capabilities and challenges of layer-fMRI VASO at 3T |
| Home > Publications Database > Evaluating the capabilities and challenges of layer-fMRI VASO at 3T |
| Journal Article | DZNE-2024-00374 |
; ; ; ; ; ; ;
2023
This record in other databases:
Please use a persistent id in citations: doi:10.52294/001c.85117
Abstract: Sub-millimeter functional imaging has the potential to capture cortical layer–specific functional information flow within and acrossbrain systems. Recent sequence advancements of fMRI signal readout and contrast generations resulted in wide adaptation oflayer-fMRI protocols across the global ultra-high-field (UHF) neuroimaging community. However, most layer-fMRI applications areconfined to one of ~100 privileged UHF imaging centers, and sequence contrasts with unwanted sensitivity to large draining veins.In this work, we propose the application of vein-signal free vascular space occupancy (VASO) layer-fMRI sequences at widely acces-sible 3T scanners. Specifically, we implement, characterize, and apply a cerebral blood volume (CBV)-sensitive VASO fMRI at a 3Tscanner setup, as it is typically used in the majority of cognitive neuroscience and clinical neuroscience fMRI studies. We find thatthe longer T2*, and stronger relative T1 contrast at 3T can account for some of the lower z-magnetization in the inversion-recoveryVASO sequence compared with 7T and 9.4T. In the main series of experiments (N=16), we test the utility of this setup for motortasks and find that—while being limited by thermal noise—3T layer-fMRI VASO is feasible within conventional scan durations. Ina series of auxiliary studies, we furthermore explore the generalizability of the developed layer-fMRI protocols for a larger rangeof study designs including as follows: visual stimulation, whole-brain movie-watching paradigms, and cognitive tasks with weakereffect sizes. We hope that the developed imaging protocols will help to increase accessibility of vein-signal free layer-fMRI imagingtools to a wider community of neuroimaging centers.
; 
|
The record appears in these collections: |
Dataset
Dataset: Evaluating the capabilities and challenges of layer-fMRI VASO at 3T
DataverseNL (2022) [10.34894/SRT8RU]
BibTeX |
EndNote:
XML,
Text |
RIS
PDF
PDF (PDFA)