Journal Article

DZNE-2024-00844

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Therapeutic Potential of Nitrogen-Doped Rutin-Bound Glucose Carbon Dots for Alzheimer's Disease.

Khan, S. ; Jatala, F. H. ; Muti, A. ; Afza, N. ; Noor, A. ; Mumtaz, S. ; Zafar, S. (Last author)DZNE*

2024
[Verlag nicht ermittelbar] New Haven, Conn.

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Please use a persistent id in citations: doi:10.59249/EWOI2166

Abstract: The blood-brain barrier (BBB) prevents the use of many drugs for the treatment of neurological disorders. Recently, nitrogen-doped carbon dots (NCDs) have emerged as promising nanocarriers to cross BBB. The primary focus of our study was to evaluate the effectiveness of NCDs for the symptomatic treatment of Alzheimer's disease (AD). In this study, we developed and characterized NCDs bound to rutin, a flavonoid with known benefits for AD. Despite its benefits, the transportation of rutin via NCDs for AD therapy has not been explored previously. We characterized the particles using FTIR and UV-visible spectroscopy followed by atomic force microscopy. Once the design was optimized and validated, we performed in vivo testing via a hemolytic assay to optimize the dosage. Preliminary in vitro testing was performed in AlCl3-induced rat models of AD whereby a single dose of 10 mg/kg NCDs-rutin was administered intraperitoneally. Interestingly, this single dose of 10 mg/kg NCDs-rutin produced the same behavioral effects as 50 mg/kg rutin administered intraperitoneally for 1 month. Similarly, histological and biomarker profiles (SOD2 and TLR4) also presented significant protective effects of NCDs-rutin against neuronal loss, inflammation, and oxidative stress. Hence, NCDs-rutin are a promising approach for the treatment of neurological diseases.

Keyword(s): Rutin: pharmacology (MeSH) ; Rutin: chemistry (MeSH) ; Animals (MeSH) ; Alzheimer Disease: drug therapy (MeSH) ; Alzheimer Disease: metabolism (MeSH) ; Carbon: chemistry (MeSH) ; Carbon: pharmacology (MeSH) ; Nitrogen: chemistry (MeSH) ; Rats (MeSH) ; Glucose: metabolism (MeSH) ; Male (MeSH) ; Quantum Dots: chemistry (MeSH) ; Disease Models, Animal (MeSH) ; Oxidative Stress: drug effects (MeSH) ; Humans (MeSH) ; Alzheimer’s disease ; Alzheimer’s disease ; Carbon dots ; neurodegeneration ; rutin ; Rutin ; Carbon ; Nitrogen ; Glucose

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Contributing Institute(s):

1. Translational Studies and Biomarker (AG Zerr)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2024

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Essential Science Indicators ; IF < 5 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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