Journal Article

DZNE-2024-00845

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Prevention of Chronic Diabetic Neuropathy and Diabetes-Associated Cognitive Impairment Using Medicinal Herbs (Cassia Angustifolia and Nigella Sativa).

Khan, M. ; Riaz, H. ; Jatala, F. H. ; Noor, A. ; Mumtaz, S. ; Zafar, S. (Last author)DZNE*

2024
[Verlag nicht ermittelbar] New Haven, Conn.

This record in other databases:    

Please use a persistent id in citations: doi:10.59249/UQLO8012

Abstract: Nodal regions, areas of intensive contact between Schwann cells and axons, may be exceptionally vulnerable to diabetes-induced changes because they are exposed to and impacted by the metabolic implications of diabetes. Insulin receptors, glucose transporters, Na+ and K+ channels, and mitochondria are abundant in nodes, all of which have been linked to the development and progression of Diabetic Peripheral Neuropathy (DPN) and Type 1 Diabetes Mellitus (T1DM)-associated cognitive impairment. Our study aimed to evaluate if the administration of Nigella sativa (NS) and Cassia angustifolia (CA) prevented diabetes-associated nervous system deficits in hyperglycemic mice. We developed T1DM mice through Streptozotocin (STZ) injections and validated the elevations in blood glucose levels. NS and CA were administered immediately upon the induction of diabetes. Behavioral analysis, histopathological evaluations, and assessment of molecular biomarkers (NR2A, MPZ, NfL) were performed to assess neuropathy and cognitive impairment. Improvements in memory, myelin loss, and the expression of synaptic proteins, even with the retention of hyperglycemia, were evident in the mice who were given a dose of herbal products upon the detection of hyperglycemia. NS was more beneficial in preventing memory impairments, demyelination, and synaptic dysfunction. The findings indicate that including these herbs in the diets of diabetic as well as pre-diabetic patients can reduce complications associated with T1DM, notably diabetic peripheral neuropathy and cognitive deficits associated with T1DM.

Keyword(s): Animals (MeSH) ; Diabetic Neuropathies: drug therapy (MeSH) ; Diabetic Neuropathies: prevention & control (MeSH) ; Nigella sativa: chemistry (MeSH) ; Mice (MeSH) ; Cognitive Dysfunction: drug therapy (MeSH) ; Cognitive Dysfunction: prevention & control (MeSH) ; Cognitive Dysfunction: etiology (MeSH) ; Male (MeSH) ; Diabetes Mellitus, Experimental: complications (MeSH) ; Diabetes Mellitus, Experimental: drug therapy (MeSH) ; Plant Extracts: pharmacology (MeSH) ; Plants, Medicinal: chemistry (MeSH) ; Senna Plant (MeSH) ; Cassia Angustifolia ; Cognitive Impairment ; Diabetic Neuropathy ; Nigella Sativa ; Streptozotocin ; Plant Extracts

---

Contributing Institute(s):

1. Translational Studies and Biomarker (AG Zerr)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2024

---

Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Essential Science Indicators ; IF < 5 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---