Journal Article

DZNE-2024-01310

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Enlarged perivascular spaces in the basal ganglia are associated with arteries not veins.

Oltmer, J. ; Mattern, H.DZNE* ; Beck, J. ; Yakupov, R.DZNE* ; Greenberg, S. M. ; Zwanenburg, J. J. ; Arts, T. ; Düzel, E.DZNE* ; van Veluw, S. J. ; Schreiber, S.DZNE* ; Perosa, V. (Last author)DZNE*

2024
Sage London

This record in other databases:    

Please use a persistent id in citations: doi:10.1177/0271678X241260629

Abstract: Enlarged perivascular spaces (EPVS) are common in cerebral small vessel disease (CSVD) and have been identified as a marker of dysfunctional brain clearance. However, it remains unknown if the enlargement occurs predominantly around arteries or veins. We combined in vivo ultra-high-resolution MRI and histopathology to investigate the spatial relationship of veins and arteries with EPVS within the basal ganglia (BG). Furthermore, we assessed the relationship between the EPVS and measures of blood-flow (blood-flow velocity, pulsatility index) in the small arteries of the BG. Twenty-four healthy controls, twelve non-CAA CSVD patients, and five probable CAA patients underwent a 3 tesla [T] and 7T MRI-scan, and EPVS, arteries, and veins within the BG were manually segmented. Furthermore, the scans were co-registered. Six autopsy-cases were also assessed. In the BG, EPVS were significantly closer to and overlapped more frequently with arteries than with veins. Histological analysis showed a higher proportion of BG EPVS surrounding arteries than veins. Finally, the pulsatility index of BG arteries correlated with EPVS volume. Our results are in line with previous works and establish a pathophysiological relationship between arteries and EPVS, contributing to elucidating perivascular clearance routes in the human brain.

Keyword(s): Humans (MeSH) ; Basal Ganglia: diagnostic imaging (MeSH) ; Basal Ganglia: blood supply (MeSH) ; Basal Ganglia: pathology (MeSH) ; Glymphatic System: diagnostic imaging (MeSH) ; Glymphatic System: pathology (MeSH) ; Glymphatic System: physiopathology (MeSH) ; Male (MeSH) ; Female (MeSH) ; Aged (MeSH) ; Cerebral Small Vessel Diseases: diagnostic imaging (MeSH) ; Cerebral Small Vessel Diseases: pathology (MeSH) ; Cerebral Small Vessel Diseases: physiopathology (MeSH) ; Magnetic Resonance Imaging (MeSH) ; Middle Aged (MeSH) ; Cerebral Arteries: diagnostic imaging (MeSH) ; Cerebral Arteries: pathology (MeSH) ; Cerebrovascular Circulation: physiology (MeSH) ; Aged, 80 and over (MeSH) ; Blood Flow Velocity (MeSH) ; Cerebral Veins: diagnostic imaging (MeSH) ; Cerebral Veins: pathology (MeSH) ; 7T MRI ; cerebral small vessel disease ; histopathology ; hypertensive arteriopathy ; perivascular clearance

---

Contributing Institute(s):

1. Clinical Neurophysiology and Memory (AG Düzel)
2. Mixed Cerebral Pathologies and Cognitive Aging (AG Schreiber)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2024

---

Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; National-Konsortium ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---