Journal Article

DZNE-2025-00111

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The Role of Atrial Fibrillation and Oral Anticoagulation Status in Health-Related Quality of Life 12 Months After Ischemic Stroke or TIA.

Olma, M. C. ; Steindorf-Sabath, L. ; Tütüncü, S. ; Kunze, C. ; Fiessler, C. ; Kirchhof, P. ; Dietzel, J. ; Schurig, J. ; Oschmann, P. ; Niehaus, L. ; Urbanek, C. ; Thomalla, G. ; Nabavi, D. G. ; Röther, J. ; Laufs, U. ; Veltkamp, R. ; Heuschmann, P. U. ; Haeusler, K. G. ; Endres, M. (Last author)DZNE* ; Investigators, M. (Collaboration Author)

2025
Wiley Malden, Mass.

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Please use a persistent id in citations: doi:10.1002/brb3.70248

Abstract: Atrial fibrillation (AF) accounts for about 20% of all ischemic strokes worldwide. It is known that AF impairs health-related quality of life (HRQOL) in the general population, but data on HRQOL in stroke patients with newly diagnosed AF are sparse.Post hoc analysis of the prospective, investigator-initiated, multicenter MonDAFIS study (NCT02204267) to analyze whether AF-related oral anticoagulation (OAC), and/or AF-symptom severity are associated with HRQOL after ischemic stroke or transient ischemic attack (TIA). HRQOL was measured using the EQ-5D-3L-questionnaire (including EQ-index/EQ-VAS) at baseline and after 12 months using multivariable linear mixed models. AF symptom severity was assessed using the European Heart Rhythm Association classification and symptom severity score (EHRA score) categorizing patients with no/mild/severe/disabling AF-related symptoms.A first episode of AF was detected in 261/2927 (8.9%) patients within 12 months after the index stroke and 227/2920 (7.8%) patients had AF and were anticoagulated at 12 months. HRQOL (measured by EQ-index, n = 2495 patients) was higher in AF patients on OAC compared to AF patients without OAC at 12 months after stroke (mean difference: MD: -16.8, 95% CI: 5.6 to 28.0), and similar in AF patients under OAC compared with patients without AF (MD: 2.0, 95% CI: -2.2 to 6.3). AF-related symptoms were negatively associated with HRQOL (measured by EQ-index) indicating that stroke patients with AF-related symptoms had a lower HRQOL compared to asymptomatic AF patients (mild vs. asymptomatic: MD: -9.0, 95% CI: -17.7 to -0.3; severe/disabling vs. asymptomatic: MD: -19.1, 95% CI: -34.7 to -3.4).Stroke patients with newly diagnosed AF are at risk of lower quality of life at 12 months, depending on OAC status and AF symptom severity.

Keyword(s): Humans (MeSH) ; Atrial Fibrillation: drug therapy (MeSH) ; Atrial Fibrillation: physiopathology (MeSH) ; Atrial Fibrillation: complications (MeSH) ; Quality of Life (MeSH) ; Female (MeSH) ; Male (MeSH) ; Anticoagulants: administration & dosage (MeSH) ; Aged (MeSH) ; Ischemic Stroke: physiopathology (MeSH) ; Ischemic Attack, Transient: physiopathology (MeSH) ; Middle Aged (MeSH) ; Prospective Studies (MeSH) ; Aged, 80 and over (MeSH) ; Administration, Oral (MeSH) ; Severity of Illness Index (MeSH) ; atrial fibrillation ; ischemic stroke ; oral anticoagulation ; quality of life ; transient ischemic attack ; Anticoagulants

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Contributing Institute(s):

1. Interdisciplinary Dementia Research (AG Endres)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2025

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