Journal Article

DZNE-2025-00380

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Factors associated with reduction in quality of life after SARS-CoV-2 infection.

Neumann, C. ; Hartung, T. J. ; Boje, K. ; Bahmer, T. ; Keil, J. ; Lieb, W. ; Franzpoetter, K. ; Welzel, J. ; Chaplinskaya-Sobol, I. ; Endres, M.DZNE* ; Geritz, J. ; Haeusler, K. G. ; Heuschmann, P. ; Hinz, A. ; Hopff, S. ; Horn, A. ; Nuernberger, C. ; Schmidbauer, L. ; Krawczak, M. ; Ruß, A.-K. ; Krist, L. ; Keil, T. ; Kudelka, J. ; Maetzler, C. ; Mehnert-Theuerkauf, A. ; Montellano, F. A. ; Morbach, C. ; Schmidt, S. ; Heyckendorf, J. ; Steigerwald, F. ; Stoerk, S. ; Lemhoefer, C. ; Schreiber, S. ; Finke, C. ; Maetzler, W.

2025
Springer Nature [London]

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Please use a persistent id in citations: doi:10.1038/s41598-025-91388-z

Abstract: Long-term changes in health-related quality of life (HrQoL) after SARS-CoV-2 infection are common, but their causes and consequences are poorly understood. This prospective, population-based study examined associations between HrQoL and 49 demographic and clinical variables. HrQoL was assessed using the European Quality-of-Life-5-Dimensions-5-Level-Version in 3,475 participants (56% female; aged 18-88 years) approximately 9 months (baseline) and 26 months (follow-up) after their initial infection. Results were compared with the demographic and clinical variables using recursive feature elimination and random forest regression analyses. A statistically significant improvement in HrQoL was observed during the observation period. At baseline, 39% of the variance in HrQoL was explained by fatigue, muscle pain, number of remaining symptoms (RS), perceived stress, and age. At follow-up, fatigue, RS, perceived stress, muscle and joint pain, and age explained 54% of the variance in HrQoL. Changes in HrQoL were associated with changes in fatigue, RS, and perceived stress, meaning that if these decreased from baseline to follow-up, then HrQoL was improved. However, it was not possible to predict whether an individual's HrQoL would improve or worsen 1 year later based on baseline variable scores. The aforementioned symptoms are specifically associated with impairment in the population's usual activities.

Keyword(s): Humans (MeSH) ; Quality of Life (MeSH) ; COVID-19: psychology (MeSH) ; COVID-19: epidemiology (MeSH) ; Female (MeSH) ; Middle Aged (MeSH) ; Adult (MeSH) ; Male (MeSH) ; Aged (MeSH) ; Aged, 80 and over (MeSH) ; Adolescent (MeSH) ; SARS-CoV-2: isolation & purification (MeSH) ; Young Adult (MeSH) ; Fatigue (MeSH) ; Prospective Studies (MeSH) ; Stress, Psychological (MeSH) ; Age ; COVID-19 ; EQ-5D-5L ; Fatigue ; Post-acute COVID-19 syndrome ; Quality of life

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Contributing Institute(s):

1. Interdisciplinary Dementia Research (AG Endres)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2025

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Linked articles:

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Journal Article (Erratum/Correction) Neumann, C. ; Hartung, T. J. ; Boje, K. ; Bahmer, T. ; Keil, J. ; Lieb, W. ; Franzpoetter, K. ; Welzel, J. ; Chaplinskaya-Sobol, I. ; Endres, M.DZNE* ; Geritz, J. ; Haeusler, K. G. ; Heuschmann, P. ; Hinz, A. ; Pütz, S. M. ; Schäfer, A. ; Nuernberger, C. ; Schmidbauer, L. ; Krawczak, M. ; Ruß, A.-K. ; Krist, L. ; Keil, T. ; Kudelka, J. ; Maetzler, C. ; Mehnert-Theuerkauf, A. ; Montellano, F. A. ; Morbach, C. ; Schmidt, S. ; Heyckendorf, J. ; Steigerwald, F. ; Stoerk, S. ; Lemhoefer, C. ; Schreiber, S. ; Finke, C. ; Maetzler, W.
Correction: How pain intensity and mental disorders shape chronic pain sick leave and quality of life in the general Spanish population.
Scientific reports 16(1), 18865 (2026) [10.1038/s41598-026-58304-5]2026   Files BibTeX | EndNote: XML, Text | RIS

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