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| Home > Publications Database > Dataset: Microglia activation orchestrates CXCL10-mediated CD8+ T cell recruitment to promote aging-related white matter degeneration |
| Home > Publications Database > Dataset: Microglia activation orchestrates CXCL10-mediated CD8+ T cell recruitment to promote aging-related white matter degeneration |
| Dataset | DZNE-2025-00414 |
2025
Gene Expression Omnibus
Abstract: Summary: Aging is the major risk factor for neurodegeneration and associated with structural and functional alterations in white matter. Myelin is particularly vulnerable to aging resulting in white matter-associated microglia activation. In this study, we employed pharmacological and genetic approaches to investigate microglial functions related to aging-associated changes in myelinated axons of mice. Our results reveal that maladaptive microglia activation promotes the accumulation of CD8+ T cells, leading to degeneration of myelinated axons and subsequent impairment of brain function and behavior. We characterize glial heterogeneity and aging-related changes in white matter by single-cell and spatial transcriptomics and reveal elaborate glial-immune interactions. Mechanistically, we show that the CXCL10-CXCR3 axis is crucial for the recruitment and retention of CD8+ T cells in aged white matter, where they exert pathogenic effects. Our results indicate that myelin-related microglia dysfunction promotes adaptive immune reactions in aging and identify putative targets to mitigate their detrimental impact. Overall design: The optic nerve were collect from mouse (adult, aged and PLX5622 treated aged) and analyzed by MERFISH.Contains 11 samples.
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