Journal Article (Review Article)

DZNE-2025-00415

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Oligodendrocytes in Alzheimer's disease pathophysiology.

Kedia, S. (First author)DZNE* ; Simons, M. (Last author)DZNE*

2025
Nature America New York, NY

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Please use a persistent id in citations: doi:10.1038/s41593-025-01873-x

Abstract: Our understanding of Alzheimer's disease (AD) has transformed from a purely neuronal perspective to one that acknowledges the involvement of glial cells. Despite remarkable progress in unraveling the biology of microglia, astrocytes and vascular elements, the exploration of oligodendrocytes in AD is still in its early stages. Contrary to the traditional notion of oligodendrocytes as passive bystanders in AD pathology, emerging evidence indicates their active participation in and reaction to amyloid and tau pathology. Oligodendrocytes undergo a functional transition to a disease-associated state, engaging in immune modulation, stress responses and cellular survival. Far from being inert players, they appear to serve a dual role in AD pathogenesis, potentially offering defense mechanisms against pathology while also contributing to disease progression. This Review explores recent advancements in understanding the roles of oligodendrocytes and their myelin sheaths in the context of AD, shedding light on their complex interactions within the disease pathology.

Keyword(s): Oligodendroglia: metabolism (MeSH) ; Alzheimer Disease: pathology (MeSH) ; Alzheimer Disease: physiopathology (MeSH) ; Alzheimer Disease: metabolism (MeSH) ; Humans (MeSH) ; Oligodendroglia: pathology (MeSH) ; Animals (MeSH) ; Myelin Sheath: pathology (MeSH) ; Oligodendroglia: physiology (MeSH) ; Myelin Sheath: metabolism (MeSH)

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Contributing Institute(s):

1. Molecular Neurobiology (AG Simons)

Research Program(s):

1. 351 - Brain Function (POF4-351) (POF4-351)

Appears in the scientific report 2025

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Nature ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 25 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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