Journal Article (Review Article)

DZNE-2025-01242

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Krankheitsmodifizierende Therapie mit Lecanemab bei früher Alzheimer-Demenz | Disease-modifying therapy with lecanemab for early Alzheimer's dementia

Hansen, N. ; Wiltfang, J. (Last author)DZNE*

2025
Thieme Stuttgart [u.a.]

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Please use a persistent id in citations: doi:10.1055/a-2681-4558

Abstract: Alzheimer's disease (AD) is a severe and progressive neurodegenerative disease of the brain that has so far been treated with symptomatic drug and non-drug therapies as standard treatment. Following the approval of the monoclonal anti-amyloid antibody by the FDA, AD therapy has changed, as this therapy has made it possible to attenuate the biological disease process of AD. Lecanemab has been recommended by the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) for approval in patients with early AD under two conditions. Firstly, homozygous ApoE4 carriers and secondly, patients receiving oral anticoagulants should not receive lecanemab. The following narrative review explains the mechanism of action, safety and side effects of lecanemab. Furthermore, risk factors for side effects are described. Finally, the first experiences with lecanemab are reported and the efficacy and financial aspects are discussed. Lecanemab leads to a temporary reduction in amyloid-ß deposits and to a benefit that can be reflected in everyday competence, cognition and quality of life and can be described as a breakthrough in AD's therapy due to its demonstrable biological and clinical efficacy.

Keyword(s): Humans (MeSH) ; Alzheimer Disease: drug therapy (MeSH) ; Alzheimer Disease: psychology (MeSH) ; Antibodies, Monoclonal, Humanized: therapeutic use (MeSH) ; Antibodies, Monoclonal, Humanized: adverse effects (MeSH) ; Amyloid beta-Peptides: metabolism (MeSH) ; Antibodies, Monoclonal, Humanized ; Amyloid beta-Peptides

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Contributing Institute(s):

1. Molecular biomarkers for predictive diagnostics of neurodegenerative diseases (AG Wiltfang)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2025

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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