Journal Article (Review Article)

DZNE-2026-00324

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Longitudinal biomarker studies in human neuroimaging: capturing biological change of Alzheimer's pathology.

Fischer, L. (First author)DZNE* ; Parker, D. ; Maboudian, S. ; Fonseca, C. ; Tato-Fernández, C. ; Annen, L. ; Arunachalam, P. ; Bacci, J. R. ; Barboure, M. ; Capelli, S. ; Karagianni, S. ; Collij, L. E. ; Edison, P. ; Fox, N. C. ; Franzmeier, N. ; Grothe, M. ; Jagust, W. J. ; Maass, A.DZNE* ; Malpetti, M. ; Paterson, R. W. ; Sogorb-Esteve, A. ; Schöll, M.

2026
BioMed Central London

This record in other databases:    

Please use a persistent id in citations: doi:10.1186/s13195-025-01920-6

Abstract: Despite extensive research, open questions about the biological underpinnings of Alzheimer’s disease (AD) remain. Neuroimaging biomarkers based on positron emission tomography (PET) and magnetic resonance imaging (MRI) offer in vivo insights into these complex biological changes and interactions. However, most evidence to date comes from cross-sectional studies, limiting our understanding of disease progression. Longitudinal studies enable the investigation of biological changes within individuals, revealing how pathology evolves over time. With this review, we provide an overview of how longitudinal imaging biomarker studies have advanced the field and how they can contribute to future research. We highlight longitudinal biomarker studies that have provided critical insights into disease trajectories, staging, and individual variability. We further assess longitudinal multimodal studies which have elucidated interactions between AD-specific pathology, amyloid-β and tau, and broader biological changes like neurodegeneration, neuronal dysfunction, vascular disease, and inflammation. Further, we discuss associations of brain changes with symptomatology and clinical outcomes and conclude with challenges and future directions.

Keyword(s): Alzheimer’s disease ; Biomarker ; Longitudinal ; MRI ; Neuroimaging ; PET

---

Contributing Institute(s):

1. Multimodal Neuroimaging (AG Maaß)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2026

---

Database coverage:
; ; ; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DOAJ Seal ; Ebsco Academic Search ; Essential Science Indicators ; Fees ; IF >= 5 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---