Journal Article

DZNE-2026-00378

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Home-based sleep monitoring reveals associations between amyloid accumulation and sleep alterations in individuals with subjective and mild cognitive impairment.

Buchal, A. M.Extern* ; Dzialas, V. ; Doering, E.Extern* ; Giehl, K. ; Bischof, G. N. ; Elmenhorst, D. ; Eimeren, T.Extern* ; Drzezga, A.DZNE* ; Hoenig, M. C. ; group, T. s. (Collaboration Author)

2026
Wiley Hoboken, NJ

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Please use a persistent id in citations: doi:10.1002/alz.71326

Abstract: Sleep disturbances have been associated with Alzheimer's disease (AD), but their relevance in preclinical stages, such as subjective cognitive decline (SCD), and their relationship with brain pathology remain unclear.We used a portable sleep-monitoring headband over four consecutive nights to assess sleep in 19 cognitively unimpaired (CU), 15 SCD, and 20 mild cognitive impairment (MCI) participants with available amyloid positron emission tomography (PET). Linear-mixed-effects models compared sleep parameters across groups, accounting for amyloid burden, age, sex, education, and recording. Regional and voxel-wise analyses examined regional associations between sleep parameters and amyloid burden.MCI patients presented reduced N3 (i.e., deep sleep), while SCD individuals showed longer N1 (i.e., light sleep) duration compared to CU. Regional amyloid burden was associated with longer light and deep sleep in amyloid-positive individuals. Higher education was linked to better sleep efficiency.Sleep changes may serve as early indicators of cognitive dysfunction and regional amyloid accumulation.

Keyword(s): Humans (MeSH) ; Cognitive Dysfunction: diagnostic imaging (MeSH) ; Cognitive Dysfunction: metabolism (MeSH) ; Cognitive Dysfunction: physiopathology (MeSH) ; Male (MeSH) ; Female (MeSH) ; Aged (MeSH) ; Positron-Emission Tomography (MeSH) ; Sleep Wake Disorders (MeSH) ; Sleep: physiology (MeSH) ; Brain: metabolism (MeSH) ; Brain: diagnostic imaging (MeSH) ; Amyloid: metabolism (MeSH) ; Aged, 80 and over (MeSH) ; Middle Aged (MeSH) ; 11C‐PiB (amyloid) PET ; EEG sleep monitoring ; cognitive impairment ; Amyloid

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Contributing Institute(s):

1. Positron Emissions Tomography (PET) (AG Boecker)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2026

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Wiley ; Essential Science Indicators ; IF >= 10 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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