Journal Article

DZNE-2026-00416

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Subjective health status, life performance and complications in chronic hypoparathyroidism - a German multicenter survey.

Fuss, C. T. ; Engbers, S. ; Reisch, N. ; Hannemann, A. ; Völzke, H. ; Grabe, H. J.DZNE* ; Nauck, M. ; Droste, M. ; Willenberg, H. S. ; Rayes, N. ; Fassnacht, M. ; Quinkler, M. ; Hahner, S.

2026
Frontiers Research Foundation Lausanne

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Please use a persistent id in citations: doi:10.3389/fendo.2026.1723640

Abstract: There is mounting evidence that conventional replacement strategies with calcium and vitamin D are insufficient to fully prevent complications of chronic hypoparathyroidism (HypoPT) in all patients.To investigate the disease burden of chronic HypoPT, we performed a survey in 205 HypoPT patients (159 females; median age 55 years; median disease duration 16 years). Patients received a disease-specific questionnaire asking for subjective health status, comorbidities, disease-related emergencies and interference of HypoPT with daily and work life. Patients were further assessed by the SF-36 questionnaire. Data was compared to sex- and age-matched subjects from the Study of Health in Pomerania SHIP-START, the German Health Interview and Examination Survey for Adults (DEGS1) and to 214 patients with adrenal insufficiency.Clinical symptoms associated with HypoPT during the past 12 months were reported by 92% of patients, requiring medical intervention in 32%. Since primary diagnosis of HypoPT, 36% of patients had presented at least once at an emergency department due to severe hypocalcemia (14.7 events per 100 patient years). Trigger factors for hypocalcemic symptoms were reported by 76% of patients (e.g. physical activity, infections, hot weather). In comparison to population-based controls, patients with HypoPT showed a higher prevalence of renal insufficiency (11% vs. 2%, p<0.001) and more frequently received antihypertensive (44% vs. 34%; p=0.003) and antiepileptic drugs (5% vs. 2%, p=0.01). Lifetime prevalence of both depression (22% vs. 15%, p=0.003) and anxiety (21% vs. 6%, p<0.001) were increased in HypoPT. SF-36 values indicated significantly reduced subjective health status in HypoPT patients compared to controls as well as patients with adrenal insufficiency.Despite established treatment, chronic HypoPT is associated with a variety of symptoms with a significant impact on daily life and work life.https://ClinicalTrials.gov/NCT03437174.

Keyword(s): Humans (MeSH) ; Female (MeSH) ; Male (MeSH) ; Hypoparathyroidism: complications (MeSH) ; Hypoparathyroidism: epidemiology (MeSH) ; Hypoparathyroidism: psychology (MeSH) ; Middle Aged (MeSH) ; Germany: epidemiology (MeSH) ; Health Status (MeSH) ; Adult (MeSH) ; Aged (MeSH) ; Quality of Life (MeSH) ; Chronic Disease (MeSH) ; Surveys and Questionnaires (MeSH) ; Health Surveys (MeSH) ; Short Form-36 ; burden of illness ; comorbidities ; hypoparathyroidism ; quality of life

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Contributing Institute(s):

1. Biomarkers of Dementia in the General Population (AG Grabe)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2026

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