Journal Article

DZNE-2026-00445

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Temporal dynamics of cognitive functioning in people with Parkinson's disease.

Scharfenberg, D. ; Kalbe, E. ; Ophey, A. ; Balzer-Geldsetzer, M. ; Berg, D. ; Hilker-Roggendorf, R. ; Kassubek, J.Extern* ; Liepelt-Scarfone, I.DZNE* ; Mollenhauer, B.Extern* ; Reetz, K. ; Riedel, O. ; Roeske, S.DZNE* ; Schulz, J. B. ; Storch, A.DZNE* ; Trenkwalder, C. ; Witt, K. ; Dodel, R. ; Deserno, M. K.

2026
Springer Nature [London]

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Please use a persistent id in citations: doi:10.1038/s41531-026-01338-3

Abstract: Cognitive domains are central to diagnosing cognitive impairment in people with Parkinson's disease (PwPD), yet are defined by expert consensus and cross-sectional data that assume temporal stability. This study examined whether cognitive domains remain stable or reorganize dynamically over time in PwPD. Using dynamic exploratory graph analysis, we analyzed 19 cognitive test scores from 355 PwPD across four yearly assessments (24,372 data points) from the DEMPARK/LANDSCAPE-study to identify dynamic organization of cognitive dimensions. Panel graphical vector autoregression models assessed dynamic couplings among dimensions. Five dynamic cognitive dimensions emerged, diverging substantially from theoretical domains and cross-sectional dimensions at baseline. Dynamic coupling revealed a temporal separation between card-sorting/cognitive flexibility and visuoconstruction. Cognitive domains in PwPD reorganize over time rather than remaining stable, challenging the static assumption of diagnostic criteria. Using PD as an exemplar, findings demonstrate the need for dynamic frameworks potentially revealing condition-specific temporal architectures when applied to other neurodegenerative disorders.

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Contributing Institute(s):

1. Parkinson Genetics (AG Gasser)
2. Neuropsychology (AG Wagner)
3. Non-Motor Symptoms in Parkinson's disease (AG Storch)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

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