Journal Article

DZNE-2026-00497

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Investigating the association of a selected inflammatory protein panel with suicide attempts in the PsyCourse Study: A pilot study.

Oraki Kohshour, M. ; Budde, M. ; Solomon, P. ; Adorjan, K. ; Heilbronner, M. ; Navarro-Flores, A. ; Reich-Erkelenz, D. ; Schulte, E. C. ; Senner, F. ; Arolt, V. ; Baune, B. T. ; Dannlowski, U. ; Fallgatter, A.Extern* ; Figge, C. ; Juckel, G. ; Reininghaus, E. Z. ; Schmauß, M. ; Wiltfang, J.DZNE* ; Falkai, P. ; Poschmann, J. ; Papiol, S. ; Heilbronner, U. ; Schulze, T. G.

2026
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.psyneuen.2026.107862

Abstract: Suicide is a significant global public health issue and expected to contribute increasingly to the global burden of disease over the coming decades. Suicide attempts are much more common than completed suicides and represent a major risk factor for and predictor of suicide. Increasing evidence links suicidal behavior to neuroinflammation, i.e., inflammatory processes in the brain. Therefore, in a subsample (n = 155) of the PsyCourse Study we investigated whether the circulating levels of 12 inflammatory proteins from the Olink® Explore 384 Inflammation Panel are associated with suicide attempts. We found significantly higher interleukin (IL)-1β levels in suicide attempters than in non-suicide attempters. Our finding indicates that the IL-1 signaling pathway plays a critical role in suicidal behavior and suggests that targeting this inflammatory pathway may help prevent suicide. This finding needs to be replicated in a larger sample.

Keyword(s): Interleukin-1 signaling ; Interleukin-1β ; Neuroinflammation ; Suicidality

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Contributing Institute(s):

1. Molecular biomarkers for predictive diagnostics of neurodegenerative diseases (AG Wiltfang)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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