Journal Article

DZNE-2026-00507

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Meningovascular Inflammation in Cerebral Amyloid Angiopathy-Related Cortical Superficial Siderosis.

Arndt, P. (First author)DZNE* ; Khadhraoui, E. ; Müller, S. J. ; Neumann, K.Extern* ; Mattern, H.DZNE* ; Meuth, S. G. ; Perosa, V. ; Charidimou, A. ; Schreiber, S. (Last author)DZNE*

2026
Wiley Chichester [u.a.]

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Please use a persistent id in citations: doi:10.1002/acn3.70315

Abstract: The role of inflammation in cortical superficial siderosis (cSS), a marker of cerebral amyloid angiopathy (CAA) linked to high hemorrhage risk, is unclear. We examined 15 patients with cSS using 3 T post-contrast vessel wall MRI (VWI) and CSF analysis. Although only 27% met current CAA-ri criteria, 93% showed vessel wall enhancement or sulcal hyperintensities near cSS, frequently extending beyond. Seven patients with follow-up VWI demonstrated corticosteroid-responsive regression of inflammation. CSF albumin quotients, indicating blood-brain barrier dysfunction, correlated with MRI inflammation scores. These findings reveal subclinical meningovascular inflammation in cSS and support VWI for detecting a broader CAA-related inflammation spectrum.

Keyword(s): Humans (MeSH) ; Cerebral Amyloid Angiopathy: complications (MeSH) ; Cerebral Amyloid Angiopathy: diagnostic imaging (MeSH) ; Cerebral Amyloid Angiopathy: cerebrospinal fluid (MeSH) ; Male (MeSH) ; Female (MeSH) ; Aged (MeSH) ; Siderosis: diagnostic imaging (MeSH) ; Siderosis: cerebrospinal fluid (MeSH) ; Siderosis: etiology (MeSH) ; Middle Aged (MeSH) ; Magnetic Resonance Imaging (MeSH) ; Aged, 80 and over (MeSH) ; Cerebral Cortex: diagnostic imaging (MeSH) ; Neuroinflammatory Diseases: diagnostic imaging (MeSH) ; Neuroinflammatory Diseases: cerebrospinal fluid (MeSH) ; Inflammation: diagnostic imaging (MeSH) ; cerebral amyloid angiopathy ; cortical superficial siderosis ; inflammation ; vessel wall imaging

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Contributing Institute(s):

1. Mixed Cerebral Pathologies and Cognitive Aging (AG Schreiber)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

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Database coverage:
; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; DEAL Wiley ; DOAJ Seal ; Ebsco Academic Search ; Essential Science Indicators ; Fees ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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