Journal Article

DZNE-2026-00574

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Differential cholinergic white matter microstructural alterations in multiple system atrophy and Parkinson's disease.

Rong, S. ; Yang, R. ; Li, Z. ; Cui, X. ; He, C. ; Zhang, P. ; Li, Y. ; Luo, Q. ; Gao, Z. ; Du, T. ; Zhang, Y. ; Cai, R. ; Liu, Z. ; Vyslouzilova, L. ; Teipel, S. J.DZNE* ; Ferreira, D. ; Nemy, M. ; Li, H. ; Wang, L. ; Cai, M. ; Zhang, Y.

2026
Elsevier [Amsterdam]

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Please use a persistent id in citations: doi:10.1016/j.nbd.2026.107449

Abstract: Multiple system atrophy (MSA) and Parkinson's disease (PD) are both α-synucleinopathies with distinct pathological features and disease courses. MSA is characterized by more extensive white matter damage and widespread cortical and subcortical cholinergic systems degeneration than PD. However, the extent and pattern of microstructural alterations of cholinergic pathways in MSA and PD remain unclear.We included 30 patients with MSA, 253 patients with PD and 46 sex- and age-matched healthy controls (HC). Probabilistic tractography was used to construct two major cholinergic pathways: from the nucleus basalis of Meynert (NBM) to cortex and from the pedunculopontine nucleus (PPN) to thalamus. Free water (FW) imaging was applied to evaluate microstructural alterations in these pathways as well as NBM and PPN. Voxel-wise analyses were assessed on localized microstructural changes and spatial heterogeneity, and receiver operating characteristic (ROC) analysis was used to evaluate the discriminatory power in differentiating MSA from PD.MSA exhibited significantly higher FW in the PPN-thalamus, NBM-external capsule, and NBM-cingulum pathways compared to both PD and HC groups (all p < 0.0001), whereas PD patients demonstrated only mild FW elevations relative to HC. In the cholinergic nuclei, FW was elevated in the PPN of MSA compared to both HC (p = 0.0168) and PD (p = 0.0097), with no significant difference between PD and HC. For NBM, FW was higher in both MSA (p = 0.0485) and PD (p = 0.0477) relative to HC but did not differ between MSA and PD. FW corrected mean diffusion (MDt) showed no difference among groups. Voxel-wise analyses revealed increased widespread FW along cholinergic pathways in MSA but not in PD. Among all regions examined, FW in the PPN-thalamus pathway showed the highest discriminatory performance (AUC = 0.786) for differentiating MSA from PD in the ROC analysis.The PPN-thalamus pathway showed the most prominent FW increase in MSA, suggesting its selective vulnerability and potential for aiding the differential diagnosis between MSA and PD. Moreover, distinct patterns of microstructural alterations highlight the spatial heterogeneity of cholinergic degeneration across α-synucleinopathies.

Keyword(s): Cholinergic pathways ; Free water imaging ; Multiple system atrophy ; Parkinson's disease ; Pedunculopontine nucleus

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Contributing Institute(s):

1. Clinical Dementia Research (Rostock /Greifswald) (AG Teipel)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

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