Journal Article

DZNE-2026-00613

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Prediction of cognitive outcome and progression to dementia using ω6-PUFA/ω3-PUFA ratio.

Andrade, V. ; Kleineidam, L.DZNE* ; Wagner-Thelen, H. ; Ballarini, T.DZNE* ; Campos-Martin, R. ; Martino-Adami, P. ; Tripathi, K. P. ; Guyonnet, S. ; Vellas, B. ; Scherer, M. ; Maier, W. ; Pentzek, M. ; Schmid, M.DZNE* ; Riedel-Heller, S. ; Weyerer, S. ; Bickel, H. ; Wiese, B. ; Egert, S. ; Wagner, M.DZNE* ; Ramírez, A. (Last author)DZNE*

2026
Wiley Hoboken, NJ

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Please use a persistent id in citations: doi:10.1002/alz.71590

Abstract: The polyunsaturated fatty acids (PUFAs) omega-6 (ω6) and omega-3 (ω3) are linked to cognitive performance and Alzheimer's-type dementia (DAT), but ω3-PUFA supplementation offers limited benefits. We propose that the ω6-PUFA/ω3-PUFA ratio better explains cognitive decline and DAT risk.PUFA profiles were examined in the AgeCoDe cohort (n = 3327) and MAPT trial (n = 1679). Cox and linear mixed models evaluated associations of individual PUFAs and the ω6-PUFA/ω3-PUFA ratio with DAT progression and cognitive decline. Mendelian randomization (MR) assessed genetic causal effects. The effect of ω3-PUFA on ω6-PUFA levels was analyzed.Higher ω6-PUFA/ω3-PUFA ratio increased DAT risk beyond ω3-PUFA levels alone. A baseline high (detrimental) ratio predicted faster cognitive decline, whereas longitudinal improvements slowed decline. MR supported a genetic non-causal link. Higher ω3-PUFA levels correlated with lower ω6-PUFA species.The ω6-PUFA/ω3-PUFA ratio better predicts cognitive decline and DAT progression than individual PUFAs, suggesting that dietary adjustments may help prevent dementia.

Keyword(s): Alzheimer's disease ; cognition ; polyunsaturated fatty acids ; prevalent neurological disorders ; ω3‐PUFA ; ω6‐PUFA

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Contributing Institute(s):

1. Patient Studies (Bonn) (Patient Studies (Bonn))
2. Neuropsychology (AG Wagner)
3. Mathematics, statistics and informatics methods for support of population studies and clinical research (AG Schmid Bonn)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Wiley ; Essential Science Indicators ; IF >= 10 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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