Journal Article

DZNE-2026-00722

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Forecast of dementia prevalence in Germany and subnational regions until 2060 using microsimulation.

Schüssel, K. ; Brückner, G. ; Schröder, H. ; Doblhammer-Reiter, G.Extern* ; Jessen, F.DZNE* ; Ernst, J. ; Caratiola, C. ; Münnich, R.

2026
Springer Nature Switzerland AG [Cham]

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Please use a persistent id in citations: doi:10.1007/s10654-026-01392-4

Abstract: The number of dementia cases is expected to rise in ageing societies with concomitant requirements for healthcare planning. While national figures for countries are widely available, subnational regional heterogeneity is rarely considered. This study aimed at projecting national and subnational dementia figures under different scenarios. Dementia and population figures where projected from 2018 to 2060 by microsimulation at the level of 400 counties within Germany. The German MikroSim model was supplemented with dementia-specific data on regional prevalence and national incidence and mortality figures. These data were derived from routine health insurance records of 27 million individuals within the AOK fund during pre-pandemic years 2017 to 2019 and adjusted to the total population of 2018. Scenarios with increasing life expectancy or prevention effects (decreasing dementia incidence by 1 to 2% per year) were calculated. Increasing life expectancy leads to dementia cases rising from 1.4 million in 2018 to 2.1 million in 2060, prevalence from 1.6 to 2.6% and the RWA (ratio of cases per 100 individuals of working age) from 2.6 to 4.7. In prevention scenarios, these figures are substantially lower: between 1.3 and 1.5 million cases, 1.6 and 1.9% prevalence and RWA between 2.9 and 3.4. Existing subnational regional differences in prevalence and RWA will become more pronounced in all scenarios. Growing life expectancy leads to an increase in dementia cases, which may be counteracted by preventive measures. Increasing regional heterogeneity in prevalence and RWA should be considered for health care planning.

Keyword(s): Humans (MeSH) ; Dementia: epidemiology (MeSH) ; Germany: epidemiology (MeSH) ; Prevalence (MeSH) ; Forecasting: methods (MeSH) ; Life Expectancy: trends (MeSH) ; Aged (MeSH) ; Female (MeSH) ; Male (MeSH) ; Aged, 80 and over (MeSH) ; Middle Aged (MeSH) ; Incidence (MeSH) ; Adult (MeSH) ; Dementia ; Germany ; Health claims data ; Microsimulation ; Prevalence ; Small area regional differences

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Contributing Institute(s):

1. Clinical Alzheimer’s Disease Research (AG Jessen)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2026

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Springer ; Essential Science Indicators ; IF >= 10 ; JCR ; National-Konsortium ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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