Journal Article

DZNE-2026-00750

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Aquaporin-4 in Narcolepsy Type 1: Investigation of Perivascular Fluid Movement in Sleep Disorders.

Ranke, J. ; Steinacker, P. ; Halbgebauer, S.Extern* ; Oeckl, P.DZNE* ; Mayer, G. ; Otto, M.

2026
Wiley Chichester [u.a.]

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Please use a persistent id in citations: doi:10.1002/acn3.70398

Abstract: Narcolepsy type 1 (NT1) is caused by the loss of hypocretin-1 leading to excessive daytime sleepiness and cataplexy. Additionally, disrupted nighttime sleep has become an increasingly recognized feature of NT1. As the glymphatic fluid movement has been linked to sleep architecture, we investigated cerebrospinal fluid (CSF) Aquaporin-4 (AQP4) as potential biomarker for perivascular fluid exchange processes in 133 NT1 patients, 145 patients with other sleeping disorders, and 62 controls. NT1 patients showed lower CSF AQP4 concentrations compared to both control groups (p < 0.0001 and p = 0.01). AQP4 levels were correlated to the CSF hypocretin-1 levels. These data suggest potential brain fluid barrier alterations in NT1.

Keyword(s): Humans (MeSH) ; Aquaporin 4: cerebrospinal fluid (MeSH) ; Narcolepsy: cerebrospinal fluid (MeSH) ; Narcolepsy: physiopathology (MeSH) ; Female (MeSH) ; Male (MeSH) ; Adult (MeSH) ; Orexins: cerebrospinal fluid (MeSH) ; Middle Aged (MeSH) ; Biomarkers: cerebrospinal fluid (MeSH) ; Glymphatic System: metabolism (MeSH) ; Glymphatic System: physiopathology (MeSH) ; Young Adult (MeSH) ; Sleep Wake Disorders: cerebrospinal fluid (MeSH) ; Aquaporin‐4 ; biomarker ; glymphatic system ; narcolepsy type 1 ; sleep disorders ; Aquaporin 4 ; AQP4 protein, human ; Orexins ; Biomarkers

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Contributing Institute(s):

1. Translational Mass Spectrometry and Biomarker Research (AG Öckl)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

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; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; DEAL Wiley ; DOAJ Seal ; Ebsco Academic Search ; Essential Science Indicators ; Fees ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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