Journal Article

DZNE-2026-00757

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Early Alzheimer´s disease blood biomarkers are associated with a higher risk for postoperative long-term cognitive decline: Insights from the FINDERI study.

Hansen, N. ; Sadlonova, M. ; Esselmann, H. ; Celano, C. M. ; Derad, C. ; Asendorf, T. ; Hohberg, M. ; Chebbok, M. ; Heinemann, S. ; Morgado, B.DZNE* ; Titsch, T. ; Packroß, K. ; Knopp, C. M. ; Becker, M.-M. ; Günther, I. ; Krasiuk, I. ; Rediske, A. I. ; Süttmann, N. P. ; Itting, P. T. ; Wirths, O. ; Kutschka, I. ; Baraki, H. ; von Arnim, C. A. F. ; Wiltfang, J. (Last author)DZNE* ; investigators, F. (Collaboration Author)

2026
Wiley Hoboken, NJ

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Please use a persistent id in citations: doi:10.1002/alz.71631

Abstract: The study aim is to investigate whether blood biomarkers (BBMs) of Alzheimer's disease (AD) pathology are associated with postoperative cognitive dysfunction (POCD) after cardiac surgery.Cognitive performance was assessed before and 12 months postoperatively using the Montreal Cognitive Assessment (MoCA) and categorized into stages-minimal (1), notable (2), and substantial (3) decline-in the FIND DElirium RIsk factors (FINDERI) study of patients undergoing cardiac surgery. BBMs were measured preoperatively (amyloid beta [Aβ]1-42, Aβ1-40, phosphorylated tau 181 [p-tau181], p-tau217, apolipoprotein E ε4 [apoE4] and apoE).A total of 394 patients completed follow-up investigations. POCD Stage 1 was observed in 105 (26.6%), POCD Stage 2 in 52 patients (13.2%), and POCD Stage 3 in 30 patients (7.6%). The AT217term (ratio Aβ1-40/1-42 * p-tau217) was significantly associated with POCD stages in multiple logistic regression.Early Alzheimer's BBMs are associated with POCD in patients, suggesting that our exploratory findings assessing BBMs may support risk stratification, inform decision-making, and contribute to strategies aimed at preventing POCD.

Keyword(s): Alzheimer´s disease ; blood biomarker ; postoperative cognitive dysfunction

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Contributing Institute(s):

1. Molecular biomarkers for predictive diagnostics of neurodegenerative diseases (AG Wiltfang)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Wiley ; Essential Science Indicators ; IF >= 10 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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