Journal Article (Review Article)

DZNE-2026-00782

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Selecting medical research data platforms for translational biomedical research: a five-tier overview and requirement-weighted assessment framework.

Jacobs, M. ; Goudarzi, S. ; Stücke, J. ; Röhm, R. ; Kanninen, T. ; Oinonen, T. ; Ritter, P. ; Schirner, M. ; Prasser, F. ; Bhagwagar, A. ; Matzenbach, B. ; Schultze, H.DZNE* ; Schultze, J.DZNE* ; Göschl, M. ; Matthies, H. ; Evans, K. R. ; Dharsee, M. ; Stephan, C. ; Belz, M. ; Gribbon, P. ; Herzog, K. ; Chen, C. ; Ruau, D. ; Dayan, I. ; Sannyasi, A. ; Kranzlmüller, D. ; Zhou, N. ; Warfsmann, J. ; Hoffmann, M. ; Schmidt, R. ; Hofmann-Apitius, M.

2026
Frontiers Media Lausanne

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Please use a persistent id in citations: doi:10.3389/fdgth.2026.1814015

Abstract: Translational biomedical research is increasingly collaborative and multimodal, making secure, high-quality data capture, curation, and analytics a major challenge. This work aims to provide an overview of existing medical research data platforms to support informed platform selection for translational biomedical research.As part of an ongoing Fraunhofer Request for Proposal (RFP) process, we developed a requirements assessment tool for users across the Fraunhofer ecosystem. In parallel, we compiled a structured overview of medical research data platforms through an open collaboration between academic and industry experts, who supplemented our market screening by identifying additional relevant platforms. Using a standardized questionnaire on key aspects of distributed data collaboration, we collected harmonized platform descriptions and organized them into a side-by-side overview with an accompanying feature weighting matrix.The study yielded a structured, comparative characterization of medical research data platforms across five functional classes, highlighting common strengths in security, interoperability, data quality, and multimodal data support. We devised (developed) a platform feature-partner weight matrix that enables context-sensitive platform scoring without imposing a predefined global ranking. In this way, users can align platform scoring with their specific translational research requirements.This structured, overview is intended to accelerate decision-making in the medical research community when choosing data platforms. By supporting context-sensitive, feature-weighted selection rather than one-size-fits-all comparisons, it acknowledges diversified research needs and can be updated as technologies and practices evolve.

Keyword(s): FAIR data ; data harmonization ; data privacy ; equirement-weighted assessment ; federated learning ; iteroperability ; medical research data platforms ; translational biomedical research

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Contributing Institute(s):

1. Clinical Single Cell Omics (CSCO) / Systems Medicine (AG Schultze)

Research Program(s):

1. 354 - Disease Prevention and Healthy Aging (POF4-354) (POF4-354)

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Database coverage:
; ; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Emerging Sources Citation Index ; Fees ; PubMed Central ; SCOPUS ; Web of Science Core Collection

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