Journal Article

DZNE-2026-00814

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Exploring Neuroinflammation and Its Role in Postoperative Cognitive Dysfunction following Spine Surgery.

Ruhnau, J. ; Müller, J. ; Nowak, S. ; Strack, S. ; Sperlich, D. ; Pohl, A. ; Dilz, J. ; Rehberg, S. ; Usichenko, T. ; Hahnenkamp, K. ; Weidemeier, M. ; Ehler, J. ; Flöel, A.DZNE* ; Schroeder, H. W. S. ; Müller, J.-U. ; Fleischmann, R. ; Vogelgesang, A.

2026
Karger Basel [u.a.]

This record in other databases:    

Please use a persistent id in citations: doi:10.1159/000548923

Abstract: Introduction: Progress in spine surgery has significantly improved the safety of procedures for older patients with disabling spine disease. However, postoperative cognitive dysfunction (POCD) remains a concern due to their link with poorer outcomes and higher long-term care risk. This study aimed to determine if pro-neuroinflammatory states accelerate neurodegeneration, contributing to POCD development, and explore whether specific biomarkers could predict POCD risk.Patients (aged ≥ 60 years) scheduled for elective spine surgery between February 2018 and March 2020 were enrolled. Biomarkers tested included IL-6, C-reactive protein, S100 calcium-binding protein β, brain-derived neurotrophic factor, serum neurofilament light chain protein (sNFL), gasdermin D, and soluble ectodomain of triggering receptor expressed on myeloid cells 2 (sTREM2), measured preoperatively and postoperatively. Cognitive outcomes were assessed using the CERAD test battery at baseline and 3 months postoperatively.Postoperative levels of sTREM2 and gasdermin D were significantly associated with cognitive performance changes 3 months after surgery, particularly in memory function. Higher sTREM2 levels were associated with greater cognitive decline, with six out of twelve CERAD items showing an inverse association (e.g., overall β = -0.010, p = 0.0003). Similarly, higher postoperative gasdermin D levels were linked to worse performance, particularly in recognition memory (e.g., word list recognition β = -0.615, p = 0.032). Additionally, higher preoperative sNFL levels were associated with poorer cognitive outcomes across multiple domains.This study highlights potential associations between neuroinflammation and cognitive decline following spine surgery. Targeting neuroinflammatory pathways could be crucial in mitigating POCD in older patients. Biomarkers may help identify high-risk patients and guide the development of targeted interventions. .

Keyword(s): Humans (MeSH) ; Male (MeSH) ; Female (MeSH) ; Postoperative Cognitive Complications: etiology (MeSH) ; Postoperative Cognitive Complications: blood (MeSH) ; Aged (MeSH) ; Biomarkers: blood (MeSH) ; Middle Aged (MeSH) ; Neuroinflammatory Diseases: blood (MeSH) ; Spine: surgery (MeSH) ; Cognitive Dysfunction: etiology (MeSH) ; Neurofilament Proteins: blood (MeSH) ; S100 Calcium Binding Protein beta Subunit: blood (MeSH) ; C-Reactive Protein: analysis (MeSH) ; Biomarker ; Delirium ; Gasdermin D ; Postoperative cognitive dysfunction ; Postoperative neurocognitive disorders ; Soluble ectodomain of triggering receptor expressed on myeloid cells 2 ; Spine surgery ; Biomarkers ; Neurofilament Proteins ; S100 Calcium Binding Protein beta Subunit ; C-Reactive Protein

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Contributing Institute(s):

1. Dementia Prevention – Mechanisms and Clinical Implementation (AG Flöel)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; National-Konsortium ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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