Journal Article

DZNE-2026-00847

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Simultaneous T2, T2*, and R2' Mapping for Multiple Sclerosis Using Nonlinear Model-Based Reconstruction of Undersampled Radial RARE-EPI MRI.

Velasquez Vides, J. R. ; Herrmann, C. J. J. ; Gladytz, T. ; Hetherington, H. P. ; Mattern, H.DZNE* ; Wang, X. ; Millward, J. M. ; Shalikar, S. ; Tellez Ceja, I. F. ; Endemann, B. ; Waiczies, S. ; Kuchling, J. ; Paul, F. ; Rose, G. ; Ku, M.-C. ; Schmitt, F. ; Niendorf, T.

2026
Wiley-Liss New York, NY [u.a.]

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Please use a persistent id in citations: doi:10.1002/mrm.70465

Abstract: To demonstrate the synergy of undersampled radial 2in1-RARE-EPI acquisition and nonlinear model-based reconstruction for accelerated and simultaneous T2, T2*, and R2' mapping in brains of patients with multiple sclerosis (MS).2in1-RARE-EPI combines a RARE module with an EPI module to capture T2 and T2* information. Nonlinear model-based reconstruction was applied to estimate T2, T2* maps directly from undersampled k-space data. A retrospective undersampling experiment was conducted to compare nonlinear model-based and parallel imaging compressed sensing (PICS) reconstruction. The proposed approach was validated and compared to reference methods multiecho spin-echo (T2, MSE) and multiecho gradient-echo (T2*, MGRE) in a phantom, healthy subjects, and MS patients.2in1-RARE-EPI together with nonlinear model-based reconstruction enabled T2, T2*, and R2' mapping with 7.5-fold scan-time acceleration relative to the references, while addressing key limitations of reference techniques, including long acquisition times, misregistration, motion and off-resonance sensitivity, and the need for calibration scans. Phantom and in vivo validation showed that the parametric maps obtained with this approach were in agreement with the reference methods. Compared with PICS, nonlinear model-based reconstruction showed more consistent spatial detail and accuracy at higher acceleration factors. The proposed method detected small focal lesions in T2, T2*, and R2' maps of MS patients and enabled visualization of the central vein sign.Scan time reduction facilitated by nonlinear model-based reconstruction of 2in1-RARE-EPI provides a technical foundation for enhanced patient compliance, and is a fundamental precursor for broader clinical studies on the potential of T2, T2*, and R2' as imaging biomarkers.

Keyword(s): Humans (MeSH) ; Multiple Sclerosis: diagnostic imaging (MeSH) ; Echo-Planar Imaging: methods (MeSH) ; Phantoms, Imaging (MeSH) ; Image Processing, Computer-Assisted: methods (MeSH) ; Brain: diagnostic imaging (MeSH) ; Nonlinear Dynamics (MeSH) ; Algorithms (MeSH) ; Retrospective Studies (MeSH) ; Adult (MeSH) ; Female (MeSH) ; Reproducibility of Results (MeSH) ; Magnetic Resonance Imaging (MeSH) ; Image Interpretation, Computer-Assisted: methods (MeSH) ; Male (MeSH) ; R2′ mapping ; central vein sign ; multiple sclerosis ; nonlinear model‐based reconstruction ; quantitative multiparametric MRI ; simultaneous T2 and T2* mapping

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Contributing Institute(s):

1. Mixed Cerebral Pathologies and Cognitive Aging (AG Schreiber)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Wiley ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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